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Gene: C55B7.8 
| C55B7.8 | SMap | S_parent | Sequence | C55B7 | ||
|---|---|---|---|---|---|---|
| Chromosome | I | |||||
| Identity (5) | ||||||
| Gene_info | Gene_class | dbr | ||||
| GO_term (7) | ||||||
| Contained_in_operon | CEOP1324 | |||||
| Structured_description | Provisional_description | dbr-1 encodes a homolog of the RNA lariat-debranching enzyme; DBR-1 is predicted to function in RNA processing by hydrolyzing the 2'-5' phosphodiester bond at the branchpoint of excised lariat intron RNA, thus converting the introns into linear molecules that can subsequently be degraded by exonucleases; in C. elegans, DBR-1 activity is required for embryonic and germline development, as well as for normal rates of postembryonic growth; overexpression of C. elegans DBR-1 in Saccharomyces cerevisiae can complement the RNA processing defects of a dbr1 null mutant strain, restoring debranching activity and intron degradation to near wild-type levels. | Paper_evidence | WBPaper00002739 | ||
| Person_evidence | WBPerson1843 | |||||
| Curator_confirmed | WBPerson1843 | |||||
| Date_last_updated | 17 Jun 2004 00:00:00 | |||||
| Concise_description | dbr-1 encodes a homolog of the RNA lariat-debranching enzyme; DBR-1 is predicted to function in RNA processing by hydrolyzing the 2'-5' phosphodiester bond at the branchpoint of excised lariat intron RNA, thus converting the introns into linear molecules that can subsequently be degraded by exonucleases; in C. elegans, DBR-1 activity is required for embryonic and germline development, as well as for normal rates of postembryonic growth; overexpression of C. elegans DBR-1 in Saccharomyces cerevisiae can complement the RNA processing defects of a dbr1 null mutant strain, restoring debranching activity and intron degradation to near wild-type levels. | |||||
| Molecular_info (6) | ||||||
| Experimental_info | RNAi_result (5) | |||||
| WB_RNAi_result (5) | ||||||
| Reference | WBPaper00002739 | |||||
| Method | Gene |
