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Gene: CD4.2   

CD4.2EvidencePaper_evidenceWBPaper00005857
SMapS_parentSequenceCD4
ChromosomeV
Identity (5)
Gene_info Gene_classcrn
Contained_in_operonCEOP5076
Structured_description Provisional_description (9)
Concise_descriptioncrn-2 encodes a cell death-related nuclease, homologous to the magnesium-dependant TatD nuclease of E. coli; CRN-2 is required for normal levels of DNA degradation during apoptosis; crn-2(RNAi) 1.5-fold stage embryos display TUNEL labelling of nuclei that is five-fold higher than that seen in untreated N2 animals; CRN-2 promotes both DNA degradation and cell corpse engulfment, in a partially redundant pathway that includes CRN-3 but is parallel to CPS-6; CRN-2 is predicted to be mitochondrial.
Molecular_info (6)
Experimental_info RNAi_result Cenix:174-f2
JA:CD4.2
WB_RNAi_result (3)
Expr_patternExpr5044
Interaction WBInteraction0002090
WBInteraction0002091
Reference WBPaper00005857
WBPaper00006283
WBPaper00019408
MethodGene