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Gene: D2023.2   

D2023.2SMapS_parentSequenceD2023
ChromosomeV
Identity (5)
Gene_info Gene_classpyc
GO_term (8)
Structured_description Provisional_descriptionpyc-1 encodes the C. elegans pyruvate carboxylase ortholog (OMIM:266150, deficiencies in humans are associated with lactic acidemia, neurological abnormalities, and early death); by homology, PYC-1 is predicted to function as a key regulatory enzyme of gluconeogenesis, lipogenesis, and anaplerosis, localizing to the mitochondrial matrix and catalyzing the formation of oxaloacetate from pyruvate and carbonate; however, loss of pyc-1 activity via large-scale RNAi screens does not result in any obvious abnormalities; pyc-1 expression is induced upon exposure of C. elegans to cadmium. Paper_evidence WBPaper00004992
WBPaper00005654
Person_evidenceWBPerson1843
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Concise_descriptionpyc-1 encodes the C. elegans pyruvate carboxylase ortholog (OMIM:266150, deficiencies in humans are associated with lactic acidemia, neurological abnormalities, and early death); by homology, PYC-1 is predicted to function as a key regulatory enzyme of gluconeogenesis, lipogenesis, and anaplerosis, localizing to the mitochondrial matrix and catalyzing the formation of oxaloacetate from pyruvate and carbonate; however, loss of pyc-1 activity via large-scale RNAi screens does not result in any obvious abnormalities; pyc-1 expression is induced upon exposure of C. elegans to cadmium.
Molecular_info (6)
Experimental_info RNAi_result Cenix:138-d4
JA:D2023.2
WB_RNAi_result JA:D2023.2
MV_SV:mv_D2023.2
Cenix:138-d4
Reference WBPaper00005859
WBPaper00004992
WBPaper00006047
WBPaper00026596
Remarksequence connection from [Freedman JH]
MethodGene