Gene: D2023.2   

D2023.2	SMap	S_parent	Sequence	D2023
	Chromosome	V
	Identity (5)
	Gene_info	Gene_class	pyc
		GO_term (8)
		Structured_description	Provisional_description	pyc-1 encodes the C. elegans pyruvate carboxylase ortholog (OMIM:266150, deficiencies in humans are associated with lactic acidemia, neurological abnormalities, and early death); by homology, PYC-1 is predicted to function as a key regulatory enzyme of gluconeogenesis, lipogenesis, and anaplerosis, localizing to the mitochondrial matrix and catalyzing the formation of oxaloacetate from pyruvate and carbonate; however, loss of pyc-1 activity via large-scale RNAi screens does not result in any obvious abnormalities; pyc-1 expression is induced upon exposure of C. elegans to cadmium.	Paper_evidence	WBPaper00004992
						WBPaper00005654
					Person_evidence	WBPerson1843
					Curator_confirmed	WBPerson1843
					Date_last_updated	17 Jun 2004 00:00:00
			Concise_description	pyc-1 encodes the C. elegans pyruvate carboxylase ortholog (OMIM:266150, deficiencies in humans are associated with lactic acidemia, neurological abnormalities, and early death); by homology, PYC-1 is predicted to function as a key regulatory enzyme of gluconeogenesis, lipogenesis, and anaplerosis, localizing to the mitochondrial matrix and catalyzing the formation of oxaloacetate from pyruvate and carbonate; however, loss of pyc-1 activity via large-scale RNAi screens does not result in any obvious abnormalities; pyc-1 expression is induced upon exposure of C. elegans to cadmium.
	Molecular_info (6)
	Experimental_info	RNAi_result (2)
		WB_RNAi_result	JA:D2023.2
			MV_SV:mv_D2023.2
			Cenix:138-d4
	Reference	WBPaper00005859
		WBPaper00004992
		WBPaper00006047
		WBPaper00026596
	Remark	sequence connection from [Freedman JH]
	Method	Gene

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