RNAiDB Tree View

Gene: E03G2.3

E03G2.3	SMap	S_parent	Sequence	E03G2
	Chromosome	X
	Identity (5)
	Gene_info	Gene_class	mec
		Reference_allele	e1340
		Allele (9)
		Phenotype	e1340 : touch insensitive lethargic; mantle of microtubule cells not stained by peanut lectin. ES2 ME3. NA > 30 (e1503ts e1504 etc. : many are ts).
			See also e1340
			[C.elegansII] e1340 : touch insensitive, lethargic; mantle of microtubule cells not stained by peanut lectin. ES2 ME3. OA>30: e1503ts, e1504, e1790 etc. (many are ts). Cloned: encodes 329 aa collagen. [Chalfie and Au 1989; Huang and Chalfie 1994; TU]
			[Gu G] A novel collagen
		Strain	CB1340
			CB1503
			CB3275
		GO_term (6)
		Structured_description	Provisional_description	mec-5 encodes a collagen unique in the number of Gly-X-Y repeats and in the composition of amino acids surrounding these repeats; MEC-5 is required for normal mechanosensory response to gentle touch and for the proper functioning of the touch receptor neurons; mec-5 interacts genetically with mec-4 and mec-10 which encode degenerins (ion channels) expressed in the touch neurons, mec-9, which encodes a protein containing EGF-like and Kunitz/protease inhibitor domains secreted by the touch neurons, and mec-12, which encodes an alpha-tubulin expressed in the touch neurons; these genetic interactions suggest that MEC-5 may play a role in anchoring the degenerin complex to the extracellular matrix; MEC-5 is produced and secreted by hypodermal cells.	Paper_evidence	WBPaper00002379
						WBPaper00005666
					Person_evidence	WBPerson1843
					Curator_confirmed	WBPerson1843
					Date_last_updated	17 Jun 2004 00:00:00
			Concise_description	mec-5 encodes a collagen unique in the number of Gly-X-Y repeats and in the composition of amino acids surrounding these repeats; MEC-5 is required for normal mechanosensory response to gentle touch and for the proper functioning of the touch receptor neurons; mec-5 interacts genetically with mec-4 and mec-10 which encode degenerins (ion channels) expressed in the touch neurons, mec-9, which encodes a protein containing EGF-like and Kunitz/protease inhibitor domains secreted by the touch neurons, and mec-12, which encodes an alpha-tubulin expressed in the touch neurons; these genetic interactions suggest that MEC-5 may play a role in anchoring the degenerin complex to the extracellular matrix; MEC-5 is produced and secreted by hypodermal cells.
	Molecular_info (6)
	Experimental_info	RNAi_result	Cenix:121-f12
			JA:E03G2.3
		WB_RNAi_result	JA:E03G2.3
			MV_SV:mv_AAA96504
			Cenix:121-f12
		Expr_pattern	Expr1624
			Expr6256
			Expr6257
		Interaction (17)
	Reference (38)
	Remark	Pseudogene tag removed because the corresponding sequence object for this gene has not been annotated as a pseudogene. This discrepancy may reflect that the sequence object was once a pseudogene and has subsequently been converted into a real gene (without this Locus object being updated). Alternatively it may be that this gene is a pseudogene in another C. elegans strain, but not in the sequenced N2 strain. [krb 030806]
	Method	Gene