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Gene: EGAP2.3   

EGAP2.3SMapS_parentSequenceEGAP2
ChromosomeII
Identity (5)
Gene_info Gene_classpho
Allele ca101 Paper_evidenceWBPaper00024976
ca102 Paper_evidenceWBPaper00024976
uCE2-1610
Phenotype [C.elegansII] ca101 : electrophoretic variant in major acidphosphatase, no other phenotype. NA1. Purified protein is homodimeric glycoprotein,55kD subunit; activity detected at luminal edge of most gut cells, but not 6 most anterior. [Beh et al. 1991; JM]
[Beh CT, McGhee JD] ca101 leads to electrophoretic variant in major acid phosphatase, no other phenotype. NA1. Purified protein is homodimeric glycoprotein, 55kD subunit, activity detected at luminal edge of most gut cells, but not 6 most anterior.
GO_termGO:0003993 IEA Inferred_automatically
Structured_description Provisional_descriptionpho-1 encodes the major C. elegans intestinal acid phosphatase; as loss of PHO-1 function via RNA-mediated interference (RNAi) does not result in any abnormalities, PHO-1 may function redundantly with other acid phosphatases; PHO-1 intestinal expression appears to be positively regulated by CKI-1, a cyclin-dependent kinase inhibitor, and negatively regulated by POP-1, a TCF/LEF transcription factor; PHO-1 is expressed along the intestinal brush border in all gut cells except the most anterior int-1 and int-2 cells, beginning at the three-fold stage of embryogenesis. Paper_evidence WBPaper00001454
WBPaper00005295
WBPaper00017091
Person_evidenceWBPerson1843
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Concise_descriptionpho-1 encodes the major C. elegans intestinal acid phosphatase; as loss of PHO-1 function via RNA-mediated interference (RNAi) does not result in any abnormalities, PHO-1 may function redundantly with other acid phosphatases; PHO-1 intestinal expression appears to be positively regulated by CKI-1, a cyclin-dependent kinase inhibitor, and negatively regulated by POP-1, a TCF/LEF transcription factor; PHO-1 is expressed along the intestinal brush border in all gut cells except the most anterior int-1 and int-2 cells, beginning at the three-fold stage of embryogenesis.
Molecular_info (5)
Experimental_info RNAi_result Cenix:204-c9
JA:EGAP2.3
WB_RNAi_result JA:EGAP2.3
MV_SV:mv_EGAP2.3
Cenix:204-c9
Expr_patternExpr3212
Reference (9)
Remark Data extracted from Beh et al. (1991)
Sequence connection from [McGhee JD]
MethodGene