RNAiDB Tree View

Gene: F07A5.7

F07A5.7	SMap	S_parent	Sequence	SUPERLINK_CB_I
	Chromosome	I
	Identity (5)
	Gene_info	Gene_class	unc
		Reference_allele	e73
		Allele (14)
		Phenotype	Probable structural gene for paramyosin. Reference allele e73 : limp paralysed phenotype larvae move slightly better Egl; disorganized muscle structure; suppressed by sup-3; e73/+ slightly slow. ES3 ME0. NA > 5 (e1214amber (more severe phenotype than e73 not suppressed by sup-3) e1402ts (moves well at 15x paralysed at 25x) etc.).
			See also e1214, e1215, e1461, s40
			[C.elegansII] e73 : limp paralysed phenotype, larvae move slightly better; Egl; disorganized muscle structure; suppressed by sup-3; e73/+ slightly slow. ES3 ME0. OA>10: e1214amb (more severe phenotype than e73, not suppressed by sup-3), e1402ts (moves well at 15C, paralysed at 25C), ut37 (lethal embryonic arrest at 4-fold stage), r404, r408, m81, s40, su228 etc. Cloned: encodes 886 aa paramyosin. Extensive structural analysis. [Kagawa et al. 1989; Gengyo-Ando and Kagawa 1991; Epstein et al. 1993; HE; HK]
		Strain (42)
		GO_term	GO:0003774	IEA	Inferred_automatically
			GO:0016459	IEA	Inferred_automatically
		Structured_description	Provisional_description	The unc-15 gene encodes a paramyosin ortholog; UNC-15 protein physically interacts with MHC A, one isoform of myosin heavy chain (MHC) in striated muscle; UNC-15 accumulation is decreased in the absence of UNC-54 (myosin B), implying that degradation of UNC-15 is inhibited by its binding myosin B; conversely, myosin B (but not MYO-3/myosin A) fails to accumulate in unc-15 mutants.	Paper_evidence	WBPaper00004378
						WBPaper00005940
					Person_evidence	WBPerson567
					Curator_confirmed	WBPerson567
					Date_last_updated	17 Jun 2004 00:00:00
				Chimeric myosin constructs show that a 322-residue region of MYO-3 (in the MHC A rod) suppresses structural and motility defects associated with the unc-15(e73) allele, whereas constructs lacking this region either have no effect on the unc-15(e73) phenotype or actually enhance it dominantly.
				Other sequences along the length of the rod may also participate in the isoform-specific interaction between MHC A and UNC-15.
			Concise_description	The unc-15 gene encodes a paramyosin ortholog; UNC-15 protein physically interacts with MHC A, one isoform of myosin heavy chain (MHC) in striated muscle; UNC-15 accumulation is decreased in the absence of UNC-54 (myosin B), implying that degradation of UNC-15 is inhibited by its binding myosin B; conversely, myosin B (but not MYO-3/myosin A) fails to accumulate in unc-15 mutants.
	Molecular_info (5)
	Experimental_info (5)
	Reference (119)
	Method	Gene