F09C12.7 | SMap | S_parent | Sequence | F09C12
|
| Chromosome | II |
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Identity (5)
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Gene_info
| Gene_class | msp
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| | Phenotype | [C.elegansII] NMK. Encodes MSP (16kD); near msp-45[Ward et al. (1988); BA] |
| | GO_term | GO:0005198
| IEA
| Inferred_automatically |
| |
Structured_description
| Provisional_description | msp-74 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. |
Paper_evidence (4)
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| | | | | Curator_confirmed | WBPerson324
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| | | | | Date_last_updated | 31 Mar 2005 00:00:00 |
| | | Concise_description | msp-74 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. |
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Molecular_info
| Corresponding_CDS | F09C12.7
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| | Corresponding_protein | WP:CE02603
|
| | Corresponding_PCR_product | sjj_F09C12.7
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Corresponding_RNAi_reagent
| Cenix:236-c7
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| | | sjj_F09C12.7
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| | | mv_F09C12.7
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Experimental_info
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RNAi_result
| Cenix:236-c7
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| | | JA:F09C12.7
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WB_RNAi_result (81)
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| | Expr_pattern | Expr3417
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Reference (4)
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Remark
| Merged msp-74ps into msp-74. krb 28/02/02 |
| | Pseudogene tag removed because the corresponding sequence object for this gene has not been annotated as a pseudogene. This discrepancy may reflect that the sequence object was once a pseudogene and has subsequently been converted into a real gene (without this Locus object being updated). Alternatively it may be that this gene is a pseudogene in another C. elegans strain, but not in the sequenced N2 strain. [krb 030806] |
| Method | Gene
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