RNAiDB Tree View

Gene: F10C1.2

F10C1.2	Evidence	CGC_data_submission
	SMap	S_parent	Sequence	F10C1
	Chromosome	II
	Identity (5)
	Gene_info	Gene_class	ifb
		Allele	ju71	Paper_evidence	WBPaper00006428
				Inferred_automatically	From strain object: CZ4380
			ok1317	Inferred_automatically	From strain object: RB1253
			cxP10878
		Phenotype	Variable abnormal morphology
		Strain	CZ4380
			RB1253
		GO_term	GO:0005198	IEA	Inferred_automatically
		Structured_description	Provisional_description (5)
			Concise_description	ifb-1 (also known as vab-21) encodes two isoforms of an essential intermediate filament protein that is coexpressed with the essential IF proteins IFA-1, IFA-2, and IFA-3, along with IFA-4; IFB-1 is required for embryonic development and epidermal morphogenesis; IFB-1 forms heteropolymeric intermediate filaments in vitro with an equimolar mixture of IFA-1, IFA-2, or IFA-3, and binds IFA-4 in blot overlay assays; IFB-1 resides in attachment structures of epidermal cells, found in sites undergoing mechanical stress; the two isoforms are expressed in different tissues and have distinct functions, since ifb-1A(RNAi) larvae have detached muscle cells, while ifb-1B(RNAi) larvae have detached cuticle.
	Molecular_info (5)
	Experimental_info (5)
	Reference (6)
	Remark	Sequence connection from [Chisholm AD]
		old_name vab-21 becomes new_name ifb-1 from [Chisholm AD].
	Method	Gene