F11A1.3 | SMap | S_parent | Sequence | F11A1
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| Chromosome | X |
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Identity (5)
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Gene_info
| Gene_class | daf
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Reference_allele
| m20
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| | | m25
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Allele (34)
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Phenotype
| m20 : defective dauer formation (daf-2 suppressible). ES1 ME3. NA1. |
| | | m25 : defective dauer formation (daf-4 suppressible). ES1 ME3. NA2. |
| | | [C.elegansII] m20 : defective dauer formation; cell migration and lineage defects. ES1 ME3 (ME0 at 25C). OA>20:m25 (pka daf-20), rh84 (distal tip cells fail to reflex, fail to express unc-5:lacZ), etc. At least six phenotypic classes;some alleles lead to heterochronic defects; some alleles enhance Age phenotype of daf-2. Cloned : encodes protein similar to nuclear hormone receptors. [Riddle et al. 1981; Hedgecock et al. 1987; DR; NJ] |
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Strain (25)
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GO_term (7)
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Structured_description
| Provisional_description | daf-12 encodes a member of the steroid hormone receptor superfamily that affects dauer formation downstream of the TGF- and insulin signaling pathways, and affects gonad-dependent adult longevity together with DAF-16, chemosensory signal transduction, and distal tip cell migration and hypodermal and intestinal cell lineages during the L3 larval stage; expressed in the nucleus and in most cells; DAF-12 is homologous to human VITAMIN D RECEPTOR (VDR; OMIM:601769, mutated in vitamin D-resistant rickets. |
Paper_evidence (7)
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| | | | | Person_evidence | WBPerson48
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| | | | | Curator_confirmed | WBPerson48
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| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Concise_description | daf-12 encodes a member of the steroid hormone receptor superfamily that affects dauer formation downstream of the TGF- and insulin signaling pathways, and affects gonad-dependent adult longevity together with DAF-16, chemosensory signal transduction, and distal tip cell migration and hypodermal and intestinal cell lineages during the L3 larval stage; expressed in the nucleus and in most cells; DAF-12 is homologous to human VITAMIN D RECEPTOR (VDR; OMIM:601769, mutated in vitamin D-resistant rickets. |
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Molecular_info (6)
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Experimental_info (5)
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Reference (222)
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| Method | Gene
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