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Gene: F11A1.3   

F11A1.3SMapS_parentSequenceF11A1
ChromosomeX
Identity (5)
Gene_info Gene_classdaf
Reference_allele m20
m25
Allele (34)
Phenotype m20 : defective dauer formation (daf-2 suppressible). ES1 ME3. NA1.
m25 : defective dauer formation (daf-4 suppressible). ES1 ME3. NA2.
[C.elegansII] m20 : defective dauer formation; cell migration and lineage defects. ES1 ME3 (ME0 at 25C). OA>20:m25 (pka daf-20), rh84 (distal tip cells fail to reflex, fail to express unc-5:lacZ), etc. At least six phenotypic classes;some alleles lead to heterochronic defects; some alleles enhance Age phenotype of daf-2. Cloned : encodes protein similar to nuclear hormone receptors. [Riddle et al. 1981; Hedgecock et al. 1987; DR; NJ]
Strain (25)
GO_term (7)
Structured_description Provisional_descriptiondaf-12 encodes a member of the steroid hormone receptor superfamily that affects dauer formation downstream of the TGF- and insulin signaling pathways, and affects gonad-dependent adult longevity together with DAF-16, chemosensory signal transduction, and distal tip cell migration and hypodermal and intestinal cell lineages during the L3 larval stage; expressed in the nucleus and in most cells; DAF-12 is homologous to human VITAMIN D RECEPTOR (VDR; OMIM:601769, mutated in vitamin D-resistant rickets. Paper_evidence (7)
Person_evidenceWBPerson48
Curator_confirmedWBPerson48
Date_last_updated17 Jun 2004 00:00:00
Concise_descriptiondaf-12 encodes a member of the steroid hormone receptor superfamily that affects dauer formation downstream of the TGF- and insulin signaling pathways, and affects gonad-dependent adult longevity together with DAF-16, chemosensory signal transduction, and distal tip cell migration and hypodermal and intestinal cell lineages during the L3 larval stage; expressed in the nucleus and in most cells; DAF-12 is homologous to human VITAMIN D RECEPTOR (VDR; OMIM:601769, mutated in vitamin D-resistant rickets.
Molecular_info (6)
Experimental_info (5)
Reference (222)
MethodGene