F11C3.2 | Evidence | CGC_data_submission |
| SMap | S_parent | Sequence | F11C3
|
| Chromosome | I |
|
Identity (5)
|
|
Gene_info
| Gene_class | unc
|
| |
Allele
| e2520
| Inferred_automatically | From strain object: CB4870 |
| | |
n2916
| Paper_evidence | WBPaper00006427
|
| | | | Inferred_automatically | From strain object: CB51 |
| | | ox79
| Paper_evidence | WBPaper00006427
|
| | Phenotype | [C.elegansII] e2520 : medium coiler at all stages. Moves forward well when stimulated, tends to coil up when moving backwards or at rest. Coiling usually ventral, occasionally dorsal. ES2 ME1/ME2. NA1. [CB] |
| |
Strain (2)
|
| |
GO_term
| GO:0006817
| IEA
| Inferred_automatically |
| | | GO:0005737
| IEA
| Inferred_automatically |
| |
Structured_description
| Provisional_description | unc-122 encodes a predicted type II transmembrane protein with extracellular collagen-like domains and a highly conserved olfactomedin (OLF) domain that is found in a family of secreted proteins involved in formation and function of nervous systems; UNC-122 is required for proper locomotion and for normal morphology of the DVB motorneuron, and may regulate neuromuscular function by acting in an aminergic/peptidergic pathway parallel to cholinergic neurotransmission; although mosaic analysis indicates that UNC-122 activity is required in muscle cells, the precise expression and localization patterns of UNC-122 are not yet known. |
Paper_evidence
| WBPaper00002665
|
| | | | | | WBPaper00012807
|
| | | | | | WBPaper00015718
|
| | | | | | WBPaper00017559
|
| | | | | Person_evidence | WBPerson1843
|
| | | | | Curator_confirmed | WBPerson1843
|
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Concise_description | unc-122 encodes a predicted type II transmembrane protein with extracellular collagen-like domains and a highly conserved olfactomedin (OLF) domain that is found in a family of secreted proteins involved in formation and function of nervous systems; UNC-122 is required for proper locomotion and for normal morphology of the DVB motorneuron, and may regulate neuromuscular function by acting in an aminergic/peptidergic pathway parallel to cholinergic neurotransmission; although mosaic analysis indicates that UNC-122 activity is required in muscle cells, the precise expression and localization patterns of UNC-122 are not yet known. |
|
Molecular_info (6)
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Experimental_info
| RNAi_result | Cenix:147-a1
|
| |
WB_RNAi_result
| MV_SV:mv_F11C3.2
|
| | | Cenix:147-a1
|
| |
Expr_pattern
| Expr2859
|
| | | Expr2860
|
| | | Expr5327
|
| |
Interaction
| WBInteraction0002346
|
| | | WBInteraction0002347
|
| | | WBInteraction0002348
|
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Reference (6)
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|
Remark
| [Hodgkin JA] extracted from complex strain CB3337, isolated by Hedgecock EM |
| | Sequence connection from [Loria P, Hobert O] |
| Method | Gene
|