F13D12.2 | SMap | S_parent | Sequence | F13D12
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| Chromosome | II |
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Identity
| Version | 1 |
| |
Name (7)
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| | Species | Caenorhabditis elegans
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| | History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971
| Event | Imported | Initial conversion from geneace |
| | Status | Live |
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Gene_info
| Gene_class | ldh
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| |
GO_term (6)
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Structured_description
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Provisional_description
| ldh-1 is orthologous to the human gene LACTATE DEHYDROGENASE B (LDHB; OMIM:150100), which when mutated leads to lactate dehydrogenase-B deficiency. | Paper_evidence | WBPaper00004424
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| | | | | Person_evidence | WBPerson567
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| | | | | Curator_confirmed | WBPerson567
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| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | | This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. |
| | | | Proteins localized to a given organelle by experiments tend to share a characteristic phylogenetic distribution of their homologs, called a phylogenetic profile. |
| | | | For instance, mitochondrial proteins can be identified effectively by their phylogenetic profiles. |
| | | | By applying phylogenetic profile analysis to the C. elegans genome, Eisenberg and coworkers inferred that this gene, along with 2-4% of all the nuclear genes in C. elegans, encodes a mitochondrial protein. |
| | | | The large fraction of organism-specific and eukaryote-derived genes suggests that C. elegans mitochondria perform specialized roles absent from prokaryotic mitochondrial ancestors. |
| | | Concise_description | ldh-1 is orthologous to the human gene LACTATE DEHYDROGENASE B (LDHB; OMIM:150100), which when mutated leads to lactate dehydrogenase-B deficiency. |
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Molecular_info (6)
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Experimental_info
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RNAi_result
| Cenix:201-g6
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| | | JA:F13D12.2
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WB_RNAi_result
| JA:F13D12.2
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| | | MV_SV:mv_AAC41613
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| | | Cenix:201-g6
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| | Expr_pattern | Expr6655
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| Method | Gene
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