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Gene: F13D12.2   

F13D12.2SMapS_parentSequenceF13D12
ChromosomeII
Identity (5)
Gene_info Gene_classldh
GO_term (6)
Structured_description Provisional_description ldh-1 is orthologous to the human gene LACTATE DEHYDROGENASE B (LDHB; OMIM:150100), which when mutated leads to lactate dehydrogenase-B deficiency.Paper_evidenceWBPaper00004424
Person_evidenceWBPerson567
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial.
Proteins localized to a given organelle by experiments tend to share a characteristic phylogenetic distribution of their homologs, called a phylogenetic profile.
For instance, mitochondrial proteins can be identified effectively by their phylogenetic profiles.
By applying phylogenetic profile analysis to the C. elegans genome, Eisenberg and coworkers inferred that this gene, along with 2-4% of all the nuclear genes in C. elegans, encodes a mitochondrial protein.
The large fraction of organism-specific and eukaryote-derived genes suggests that C. elegans mitochondria perform specialized roles absent from prokaryotic mitochondrial ancestors.
Concise_descriptionldh-1 is orthologous to the human gene LACTATE DEHYDROGENASE B (LDHB; OMIM:150100), which when mutated leads to lactate dehydrogenase-B deficiency.
Molecular_info (6)
Experimental_info RNAi_result Cenix:201-g6
JA:F13D12.2
WB_RNAi_result JA:F13D12.2
MV_SV:mv_AAC41613
Cenix:201-g6
Expr_patternExpr6655
MethodGene