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Gene: F13D12.2 
| F13D12.2 | SMap | S_parent | Sequence | F13D12 | ||
|---|---|---|---|---|---|---|
| Chromosome | II | |||||
| Identity (5) | ||||||
| Gene_info | Gene_class | ldh | ||||
| GO_term (6) | ||||||
| Structured_description | Provisional_description | ldh-1 is orthologous to the human gene LACTATE DEHYDROGENASE B (LDHB; OMIM:150100), which when mutated leads to lactate dehydrogenase-B deficiency. | Paper_evidence | WBPaper00004424 | ||
| Person_evidence | WBPerson567 | |||||
| Curator_confirmed | WBPerson567 | |||||
| Date_last_updated | 17 Jun 2004 00:00:00 | |||||
| This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. | ||||||
| Proteins localized to a given organelle by experiments tend to share a characteristic phylogenetic distribution of their homologs, called a phylogenetic profile. | ||||||
| For instance, mitochondrial proteins can be identified effectively by their phylogenetic profiles. | ||||||
| By applying phylogenetic profile analysis to the C. elegans genome, Eisenberg and coworkers inferred that this gene, along with 2-4% of all the nuclear genes in C. elegans, encodes a mitochondrial protein. | ||||||
| The large fraction of organism-specific and eukaryote-derived genes suggests that C. elegans mitochondria perform specialized roles absent from prokaryotic mitochondrial ancestors. | ||||||
| Concise_description | ldh-1 is orthologous to the human gene LACTATE DEHYDROGENASE B (LDHB; OMIM:150100), which when mutated leads to lactate dehydrogenase-B deficiency. | |||||
| Molecular_info | Corresponding_CDS | F13D12.2 | ||||
| Corresponding_protein | WP:CE02181 | |||||
| KOG | KOG1495 | |||||
| Corresponding_PCR_product | smd_F13D12.2 | |||||
| sjj_F13D12.2 | ||||||
| Corresponding_RNAi_reagent | Cenix:201-g6 | |||||
| sjj_F13D12.2 | ||||||
| mv_AAC41613 | ||||||
| Other_sequence | L43563 | |||||
| U15420 | ||||||
| Experimental_info | RNAi_result | Cenix:201-g6 | ||||
| JA:F13D12.2 | ||||||
| WB_RNAi_result | JA:F13D12.2 | |||||
| MV_SV:mv_AAC41613 | ||||||
| Cenix:201-g6 | ||||||
| Expr_pattern | Expr6655 | |||||
| Method | Gene |
