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Gene: F13D12.7   

F13D12.7SMapS_parentSequenceSUPERLINK_CB_II
ChromosomeII
Identity Version1
Name (7)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:25WBPerson1971 EventImportedInitial conversion from geneace
StatusLive
Gene_info Gene_classgpb
Allele pk13
pk44 Inferred_automatically From strain object: NL344
From strain object: NL361
Phenotype[C.elegansII] pk13. Tc1 insertion, also excision derivatives pk44: recessive lethal, arrests at L1 stage with very little body wall or pharyngeal muscle activity. In absence of maternal rescue, probably arrests as early embryonic lethal. [NL; JA]
Strain (2)
GO_term (7)
Structured_description Provisional_descriptiongpb-1 encodes a heterotrimeric G protein beta subunit that is required during embryonic development for the proper orientation of the mitotic spindle during early cell divisions and thus affects the orientation of early cell division axes, and is also required for larval viability, negatively regulates locomotion and egg-laying, and may affect germline development and osmotic balance; expressed in early embryos with highest expression at cell membranes and colocalizes with asters just before and during early cell divisions (this localization is dependent upon G alpha subunits); adults display high levels of expression in neurons with lower expression in the somatic gonad, vulva, and hypodermal seam cells and expression is also detected in the intestine, pharynx, body wall muscles and in the germline. Paper_evidence WBPaper00002525
WBPaper00004576
WBPaper00005878
Person_evidenceWBPerson48
Curator_confirmedWBPerson48
Date_last_updated17 Jun 2004 00:00:00
Concise_descriptiongpb-1 encodes a heterotrimeric G protein beta subunit that is required during embryonic development for the proper orientation of the mitotic spindle during early cell divisions and thus affects the orientation of early cell division axes, and is also required for larval viability, negatively regulates locomotion and egg-laying, and may affect germline development and osmotic balance; expressed in early embryos with highest expression at cell membranes and colocalizes with asters just before and during early cell divisions (this localization is dependent upon G alpha subunits); adults display high levels of expression in neurons with lower expression in the somatic gonad, vulva, and hypodermal seam cells and expression is also detected in the intestine, pharynx, body wall muscles and in the germline.
Molecular_info (6)
Experimental_info (4)
Reference (40)
MethodGene