RNAiDB Tree View

Gene: F14F3.1

F14F3.1	SMap	S_parent	Sequence	F14F3
	Chromosome	X
	Identity (5)
	Gene_info	Gene_class	vab
		Laboratory	EM
		Reference_allele	e648
		Allele (31)
		Phenotype (6)
		Strain (8)
		GO_term (7)
		Structured_description	Provisional_description	vab-3 encodes a homeodomain protein that is the C. elegans Pax-6 orthologue; during development, vab-3 activity is required for proper patterning of anterior (head) hypodermal cells; vab-3 effects head development, in part, through positively regulating transcription of ceh-32, a Six/sine oculis class homeobox gene coexpressed with vab-3 in head hypodermis.	Paper_evidence	WBPaper00002236
						WBPaper00004825
					Curator_confirmed	WBPerson1843
					Date_last_updated	09 Aug 2005 00:00:00
				The vab-3 gene (also known as mab-18) encodes an ortholog of human PAX6, which when mutated leads to aniridia (OMIM:106210).	Paper_evidence	WBPaper00004103
					Person_evidence	WBPerson567
			Concise_description	vab-3 encodes a homeodomain protein that is the C. elegans Pax-6 orthologue; during development, vab-3 activity is required for proper patterning of anterior (head) hypodermal cells; vab-3 effects head development, in part, through positively regulating transcription of ceh-32, a Six/sine oculis class homeobox gene coexpressed with vab-3 in head hypodermis.
				The vab-3 gene (also known as mab-18) encodes an ortholog of human PAX6, which when mutated leads to aniridia (OMIM:106210).
	Molecular_info (7)
	Experimental_info (6)
	Reference (80)
	Remark	vab-3 only corresponds to F14F3.1a whereas mab-18 corresponds to the splice variants F14F3.1b and F14F3.1c
		mab-18 corresponds only to F14F3.1b and F14F3.1c. The first splice variant (F14F3.1a) corresponds to the vab-3 gene.
	Method	Gene