RNAiDB Tree View

Gene: F15A2.6

F15A2.6	Evidence	CGC_data_submission
	SMap	S_parent	Sequence	F15A2
	Chromosome	X
	Identity (5)
	Gene_info	Gene_class	sad
		Allele (8)
		Strain	CX5156
		GO_term (13)
		Structured_description	Provisional_description	sad-1 encodes a novel serine/threonine protein kinase; SAD-1 activity is required for several aspects of presynaptic development, including termination of axon outgrowth and presynaptic vesicle clustering, in GABAergic motor neurons and the ASI amphid chemosensory neuron; in addition, overexpression studies suggest that SAD-1 may also play a role in regulating axonal-dendritic polarity; SAD-1 is expressed in the nervous system, where it localizes asymmetrically to the synapse-rich regions of axons.	Paper_evidence	WBPaper00004523
						WBPaper00024525
					Curator_confirmed	WBPerson1843
					Date_last_updated	25 Jan 2005 00:00:00
				Sequence similarity between SAD-1 and the PAR-1 and MARK-type protein kinases suggest that SAD-1 could play a role in organizing the microtubule network adjacent to synapses to determine the site of vesicle accumulation.
			Concise_description	sad-1 encodes a novel serine/threonine protein kinase; SAD-1 activity is required for several aspects of presynaptic development, including termination of axon outgrowth and presynaptic vesicle clustering, in GABAergic motor neurons and the ASI amphid chemosensory neuron; in addition, overexpression studies suggest that SAD-1 may also play a role in regulating axonal-dendritic polarity; SAD-1 is expressed in the nervous system, where it localizes asymmetrically to the synapse-rich regions of axons.
	Molecular_info (6)
	Experimental_info	RNAi_result (12)
		WB_RNAi_result (13)
		Expr_pattern	Expr812
			Expr813
			Expr814
			Expr5163
	Reference (13)
	Remark	[email 93 from R. Lee and cgc4523]
	Method	Gene