RNAiDB Tree View

Gene: F17E5.1

F17E5.1	SMap	S_parent	Sequence	F17E5
	Chromosome	X
	Identity (5)
	Gene_info	Gene_class	lin
		Reference_allele	e1309
		Allele (25)
		Phenotype	e1309 : adult hermaphrodite vulvaless (penetrance 93%); ES2 (adult)/ ES1 (larvae); HME2; adult male wildtype ME3. NA13 (e1453amber (non-null lower penetrance than e1309 50% vulvaless) n105ts (penetrance 24% at 15x 90% at 25x) n768 (weak allele multiple vulval protrusions penetrance 21%) etc.).
			See also e1309, e1424, e1437, e1453, n105, n167, n305, n380, n670, n674, n768, n1052, n1297, n1298
			[C.elegansII] e1309 : adult hermaphrodite vulvaless (penetrance 93%); ES2 (adult)/ ES1 (larvae); HME2; adult male wildtype ME3. NA13: e1453amb (non-null, lower penetrance than e1309, 50% vulvaless), n105ts (penetrance 24% at 15C, 90% at 25C) n768 (weak allele multiple vulval protrusions penetrance 21%), n397 (deletes most of gene), etc. Cloned: encodes predicted protein with PDZ domain,similarity to guanylate kinase, Drosophila discs large. Mutants delocalize LET-23. [Ferguson et al. 1985; SD; MT]
		Strain (7)
		GO_term (6)
		Structured_description	Provisional_description	lin-2 encodes a protein belonging to the membrane associated guanylate kinase (MAGUK) family, with several domains (L27, PDZ, SH3, and guanylate kinase) thought to assemble specific multiprotein complexes in particular regions of the cell; in vivo, LIN-2 is required for the correct localization of LET-23 (and, presumably, other membrane proteins) to specific regions of the plasma membrane.	Paper_evidence	WBPaper00003215
						WBPaper00004424
					Person_evidence	WBPerson567
					Curator_confirmed	WBPerson567
					Date_last_updated	17 Jun 2004 00:00:00
				This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial.
			Concise_description	lin-2 encodes a protein belonging to the membrane associated guanylate kinase (MAGUK) family, with several domains (L27, PDZ, SH3, and guanylate kinase) thought to assemble specific multiprotein complexes in particular regions of the cell; in vivo, LIN-2 is required for the correct localization of LET-23 (and, presumably, other membrane proteins) to specific regions of the plasma membrane.
	Molecular_info (7)
	Experimental_info	RNAi_result	Cenix:147-c4
			JA:F17E5.1
		WB_RNAi_result	SA:yk213c8
			JA:F17E5.1
			MV_SV:mv_CAA63314
			Cenix:147-c4
		Interaction (17)
	Reference (123)
	Method	Gene