Gene: F26B1.7
F26B1.7 | SMap | S_parent | Sequence | F26B1 | ||
---|---|---|---|---|---|---|
Chromosome | I | |||||
Identity (5) | ||||||
Gene_info | Gene_class | let | ||||
Allele | gk302 | Inferred_automatically | From strain object: VC706 | |||
h107 | Inferred_automatically | From strain object: KR429 | ||||
tm288 | ||||||
Phenotype | [McDowall JS] Early larval lethal | |||||
[C.elegansII] h107 : embryonic or early larval lethal. OA2: h495, h747. Cloned (cosmid F26B1). [Howell et al. 1987; KR] | ||||||
Strain | KR429 | |||||
VC706 | ||||||
GO_term | GO:0003700 | IEA | Inferred_automatically | |||
GO:0006355 | IEA | Inferred_automatically | ||||
GO:0005634 | IEA | Inferred_automatically | ||||
Structured_description | Provisional_description | let-381 encodes a forkhead transcription factor and was identified in a screen for essential genes; let-381 is essential for development at different times as mutants exhibit embryonic and early larval lethality, with a few developing to sterile adults; inactivation of let-381 using RNA interference results in adults with mesodermal cell lineage defects and a reduced number of coelomocytes; reporter-gene assays indicate LET-318 is expressed when the embryo starts to elongate and continues to be expressed through all larval stages and into the adult. | Paper_evidence (5) | |||
Person_evidence | WBPerson381 | |||||
Curator_confirmed | WBPerson381 | |||||
Date_last_updated | 17 Jun 2004 00:00:00 | |||||
Concise_description | let-381 encodes a forkhead transcription factor and was identified in a screen for essential genes; let-381 is essential for development at different times as mutants exhibit embryonic and early larval lethality, with a few developing to sterile adults; inactivation of let-381 using RNA interference results in adults with mesodermal cell lineage defects and a reduced number of coelomocytes; reporter-gene assays indicate LET-318 is expressed when the embryo starts to elongate and continues to be expressed through all larval stages and into the adult. | |||||
Molecular_info (5) | ||||||
Experimental_info | RNAi_result | Cenix:147-c7 | ||||
JA:F26B1.7 | ||||||
Simmer:F26B1.7:Screen_A | ||||||
Simmer:F26B1.7:Screen_B | ||||||
WB_RNAi_result | JA:F26B1.7 | |||||
Simmer:F26B1.7:Screen_A | ||||||
Simmer:F26B1.7:Screen_B | ||||||
Cenix:147-c7 | ||||||
Expr_pattern | Expr2343 | |||||
Expr2344 | ||||||
Reference | WBPaper00002830 | |||||
WBPaper00002829 | ||||||
WBPaper00000975 | ||||||
WBPaper00011551 | ||||||
WBPaper00016924 | ||||||
WBPaper00018404 | ||||||
WBPaper00019541 | ||||||
Remark | [McDowall JS] Extrachromosomal array containing three cosmids generated, then manipulated genetically. Rescuing cosmids deduced from experiments with other arrays. Rescuing array contained both positive clones. | |||||
Method | Gene |