F26B1.7 | SMap | S_parent | Sequence | F26B1
|
| Chromosome | I |
|
Identity (5)
|
|
Gene_info
| Gene_class | let
|
| |
Allele (3)
|
| |
Phenotype
| [McDowall JS] Early larval lethal |
| | | [C.elegansII] h107 : embryonic or early larval lethal. OA2: h495, h747. Cloned (cosmid F26B1). [Howell et al. 1987; KR] |
| |
Strain
| KR429
|
| | | VC706
|
| |
GO_term
| GO:0003700
| IEA
| Inferred_automatically |
| | | GO:0006355
| IEA
| Inferred_automatically |
| | | GO:0005634
| IEA
| Inferred_automatically |
| |
Structured_description
| Provisional_description | let-381 encodes a forkhead transcription factor and was identified in a screen for essential genes; let-381 is essential for development at different times as mutants exhibit embryonic and early larval lethality, with a few developing to sterile adults; inactivation of let-381 using RNA interference results in adults with mesodermal cell lineage defects and a reduced number of coelomocytes; reporter-gene assays indicate LET-318 is expressed when the embryo starts to elongate and continues to be expressed through all larval stages and into the adult. |
Paper_evidence (5)
|
| | | | | Person_evidence | WBPerson381
|
| | | | | Curator_confirmed | WBPerson381
|
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Concise_description | let-381 encodes a forkhead transcription factor and was identified in a screen for essential genes; let-381 is essential for development at different times as mutants exhibit embryonic and early larval lethality, with a few developing to sterile adults; inactivation of let-381 using RNA interference results in adults with mesodermal cell lineage defects and a reduced number of coelomocytes; reporter-gene assays indicate LET-318 is expressed when the embryo starts to elongate and continues to be expressed through all larval stages and into the adult. |
|
Molecular_info (5)
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Experimental_info
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RNAi_result
| Cenix:147-c7
|
| | | JA:F26B1.7
|
| | | Simmer:F26B1.7:Screen_A
|
| | | Simmer:F26B1.7:Screen_B
|
| |
WB_RNAi_result
| JA:F26B1.7
|
| | | Simmer:F26B1.7:Screen_A
|
| | | Simmer:F26B1.7:Screen_B
|
| | | Cenix:147-c7
|
| |
Expr_pattern
| Expr2343
|
| | | Expr2344
|
|
Reference (7)
|
| Remark | [McDowall JS] Extrachromosomal array containing three cosmids generated, then manipulated genetically. Rescuing cosmids deduced from experiments with other arrays. Rescuing array contained both positive clones. |
| Method | Gene
|