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Gene: F26B1.7   

F26B1.7SMapS_parentSequenceF26B1
ChromosomeI
Identity (5)
Gene_info Gene_classlet
Allele gk302 Inferred_automaticallyFrom strain object: VC706
h107 Inferred_automaticallyFrom strain object: KR429
tm288
Phenotype [McDowall JS] Early larval lethal
[C.elegansII] h107 : embryonic or early larval lethal. OA2: h495, h747. Cloned (cosmid F26B1). [Howell et al. 1987; KR]
Strain (2)
GO_term GO:0003700 IEA Inferred_automatically
GO:0006355 IEA Inferred_automatically
GO:0005634 IEA Inferred_automatically
Structured_description Provisional_descriptionlet-381 encodes a forkhead transcription factor and was identified in a screen for essential genes; let-381 is essential for development at different times as mutants exhibit embryonic and early larval lethality, with a few developing to sterile adults; inactivation of let-381 using RNA interference results in adults with mesodermal cell lineage defects and a reduced number of coelomocytes; reporter-gene assays indicate LET-318 is expressed when the embryo starts to elongate and continues to be expressed through all larval stages and into the adult. Paper_evidence (5)
Person_evidenceWBPerson381
Curator_confirmedWBPerson381
Date_last_updated17 Jun 2004 00:00:00
Concise_descriptionlet-381 encodes a forkhead transcription factor and was identified in a screen for essential genes; let-381 is essential for development at different times as mutants exhibit embryonic and early larval lethality, with a few developing to sterile adults; inactivation of let-381 using RNA interference results in adults with mesodermal cell lineage defects and a reduced number of coelomocytes; reporter-gene assays indicate LET-318 is expressed when the embryo starts to elongate and continues to be expressed through all larval stages and into the adult.
Molecular_info (5)
Experimental_info RNAi_result Cenix:147-c7
JA:F26B1.7
Simmer:F26B1.7:Screen_A
Simmer:F26B1.7:Screen_B
WB_RNAi_result JA:F26B1.7
Simmer:F26B1.7:Screen_A
Simmer:F26B1.7:Screen_B
Cenix:147-c7
Expr_pattern Expr2343
Expr2344
Reference (7)
Remark[McDowall JS] Extrachromosomal array containing three cosmids generated, then manipulated genetically. Rescuing cosmids deduced from experiments with other arrays. Rescuing array contained both positive clones.
MethodGene