RNAiDB Tree View

Gene: F31E3.5

F31E3.5	SMap	S_parent	Sequence	F31E3
	Chromosome	III
	Identity (5)
	Gene_info	Gene_class	eft
		Allele	q145	Inferred_automatically	From strain object: JK1774
			ar229	Paper_evidence	WBPaper00024924
		Phenotype	[C.elegansII] NMK. Encodes 463 aa protein with 83% identity to EF1alpha. eft-3:lacZ fusion expressed widely, but not in intestine or body wall muscle. [FK]
			[C.elegansII] q145 : sterile, no germ line proliferation in hermaphrodites or males; about 3 undifferentiated germ cells per gonad arm. No somatic defects. OA4: q156, q171, q363, q456 (all similar). [JK]
			[Kadyk LC] Homozygous q145 adults have germ lines with very few cells and no differentiated gametes, no somatic defects, hermaphrodites and males similarly affected. More proliferations at 25C, still sterile. Similar, slightly weaker phenotype in q145/sDf127. OA4: q156 possibly stronger allele.
		Strain	JK1774
		GO_term (5)
		Structured_description	Provisional_description	eft-3 encodes a translation elongation factor 1-alpha homolog that is required for embryonic viability, fertility, and germline maintenance; the EFT-3 protein sequence is encoded both by eft-3 (F31E3.5) itself but also by R03G5.1.	Paper_evidence	WBPaper00004313
						WBPaper00004403
						WBPaper00004651
					Person_evidence	WBPerson567
					Curator_confirmed	WBPerson567
					Date_last_updated	17 Jun 2004 00:00:00
				Paralogs are encoded by H19N07.1, K07A12.4, and other genes.
				eft-3 expression is unaffected by smg mutations (unlike other translation-related genes such as rpl-3, rpl-7, rpl-10, or rpl-12.
			Concise_description	eft-3 encodes a translation elongation factor 1-alpha homolog that is required for embryonic viability, fertility, and germline maintenance; the EFT-3 protein sequence is encoded both by eft-3 (F31E3.5) itself but also by R03G5.1.
	Molecular_info (5)
	Experimental_info	RNAi_result (5)
		WB_RNAi_result (11)
		Expr_pattern (2)
	Reference (16)
	Method	Gene