RNAiDB Tree View

Gene: F32D8.6

F32D8.6	SMap	S_parent	Sequence	F32D8
	Chromosome	V
	Identity (5)
	Gene_info	Gene_class	emo
		Allele	oz1	Inferred_automatically	From strain object: BS5182
		Phenotype	[Iwasaki K] oocyte diakinesis arrest defective. Hermaphrodite sterile. In hermaphrodite, unfertilized oocytes in diakinesis undergo DNA endoreduplication and become polyploid.
			[C.elegansII] oz1 : oocyte diakinesis arrest defective. Hermaphrodite sterile. In hermaphrodite, unfertilized oocytes in diakinesis undergo DNA endoreduplication and become polyploid. OA1: oz151 (embryonic lethal). Cloned : cosmid F32D8[BS]
		Strain	BS5182
		GO_term (8)
		Structured_description	Provisional_description	emo-1 encodes an ortholog of S. cerevisiae Sec61p gamma subunit, which is required for translocation of secreted and membrane proteins into the endoplasmic reticulum; EMO-1 is required for oogenesis and ovulation.	Paper_evidence	WBPaper00002519
					Person_evidence	WBPerson567
					Curator_confirmed	WBPerson567
					Date_last_updated	17 Jun 2004 00:00:00
				emo-1(oz151) null mutants are embryonic lethal; with the germline-specific allele emo-1(oz1), mutants fail to ovulate after meiotic maturation, leading to endomitosis of oocytes in the gonad arm.
				emo-1(oz1) oocytes fail to stain with an antibody (J67) which recognizes a surface antigen of oocytes, indicating that emo-1(oz1) blocks protein transport.
				A model for EMO-1 function is that it promotes the synthesis of a secreted or surface protein of oocytes which, in turn, is required for the oocyte to signal the sheath, the spermetheca, or both after meiotic maturation.
			Concise_description	emo-1 encodes an ortholog of S. cerevisiae Sec61p gamma subunit, which is required for translocation of secreted and membrane proteins into the endoplasmic reticulum; EMO-1 is required for oogenesis and ovulation.
	Molecular_info (6)
	Experimental_info	RNAi_result	Cenix:139-d1
		WB_RNAi_result	MV_SV:mv_F32D8.6
			Cenix:139-d1
		Expr_pattern	Expr1565
	Reference (18)
	Method	Gene