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Gene: F33D4.1 
| F33D4.1 | Evidence | Paper_evidence | WBPaper00003416 | |||
|---|---|---|---|---|---|---|
| WBPaper00004181 | ||||||
| SMap | S_parent | Sequence | F33D4 | |||
| Chromosome | IV | |||||
| Identity (5) | ||||||
| Gene_info | Gene_class | nhr | ||||
| Allele | ok186 | Inferred_automatically | From strain object: AE501 | |||
| tm1800 | ||||||
| uCE4-1011 | ||||||
| uCE4-1012 | ||||||
| Phenotype | NMK. Nuclear hormone receptor superfamily. [AE] | |||||
| [C.elegansII] NMK. Nuclear hormone receptor superfamily. YAC Y50A3 etc. [AE] | ||||||
| Strain | AE501 | |||||
| GO_term (6) | ||||||
| Structured_description | Provisional_description | The nhr-8 gene encodes a nuclear hormone receptor homolog; nhr-8(ok186) mutants have abnormally low resistance to the toxins colchicine and chloroquine. | Paper_evidence | WBPaper00004723 | ||
| Person_evidence | WBPerson567 | |||||
| Curator_confirmed | WBPerson567 | |||||
| Date_last_updated | 17 Jun 2004 00:00:00 | |||||
| This resembles the regulation of protective metabolic enzymes by xenobiotic-sensing nuclear receptors, and might thus be a process generally conserved in metazoa. | ||||||
| nhr-8 is cotranscribed in the gut with the the ABC transporter gene, pgp-3; however, unlike pgp-3 mutants, nhr-8 mutants have normal sensitivity to pyocyanin-dependent killing by Pseudomonas aeruginosa. | ||||||
| NHR-8 may thus mediate a subset of the resistance traits promoted by PGP-3. | ||||||
| Concise_description | The nhr-8 gene encodes a nuclear hormone receptor homolog; nhr-8(ok186) mutants have abnormally low resistance to the toxins colchicine and chloroquine. | |||||
| Molecular_info (6) | ||||||
| Experimental_info | RNAi_result | JA:F33D4.1 | ||||
| [cgc5655]:F33D4.1 | ||||||
| Cenix:18-g5 | ||||||
| WB_RNAi_result | JA:F33D4.1 | |||||
| [cgc5655]:F33D4.1 | ||||||
| MV_SV:mv_AAD03684 | ||||||
| Cenix:18-g5 | ||||||
| Expr_pattern | Expr1351 | |||||
| Reference (10) | ||||||
| Remark | cm14e12 unnecessary in sequence list. sdm 11/00 | |||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
| Method | Gene |
