RNAiDB Tree View

Gene: F35G12.3

F35G12.3	Evidence	CGC_data_submission
	SMap	S_parent	Sequence	F35G12
	Chromosome	III
	Identity (5)
	Gene_info	Gene_class	sel
		Allele	n1250
			n1254	Inferred_automatically	From strain object: MT3000
			ok149	Inferred_automatically	From strain object: GS2381
			ok363	Inferred_automatically	From strain object: RB638
		Phenotype	[C.elegansII] n1524 : suppressor of lin-12 hypermorphs (n302sd, etc.). Mosaic analysis indicates focus in VU not AC. [JT; MT]
		Strain	GS2381
			MT3000
			RB638
		GO_term	GO:0004672	IEA	Inferred_automatically
			GO:0005524	IEA	Inferred_automatically
			GO:0006468	IEA	Inferred_automatically
			GO:0004674	IEA	Inferred_automatically
		Structured_description	Provisional_description	sel-5 encodes a serine/threonine kinase most similar to mammalian GAK1 and Saccharomyces cerevisiae Pak1p; SEL-5 is required for LIN-12/Notch-mediated signaling events that instruct cells of equivalent developmental potential to adopt distinct fates; sel-5 encodes two protein kinase isoforms generated from alternatively spliced mRNAs and appears to influence cell fate decisions by acting before or during ligand-dependent release of the LIN-12 intracellular domain.	Paper_evidence	WBPaper00003827
					Person_evidence	WBPerson1843
					Curator_confirmed	WBPerson1843
					Date_last_updated	17 Jun 2004 00:00:00
			Concise_description	sel-5 encodes a serine/threonine kinase most similar to mammalian GAK1 and Saccharomyces cerevisiae Pak1p; SEL-5 is required for LIN-12/Notch-mediated signaling events that instruct cells of equivalent developmental potential to adopt distinct fates; sel-5 encodes two protein kinase isoforms generated from alternatively spliced mRNAs and appears to influence cell fate decisions by acting before or during ligand-dependent release of the LIN-12 intracellular domain.
	Molecular_info (5)
	Experimental_info	RNAi_result (5)
		WB_RNAi_result (8)
		Expr_pattern	Expr1082
			Expr5020
		Interaction	WBInteraction0000980
	Reference (5)
	Remark	[Iva Greenwald] published in Fares and Greenwald, Genetics 153, 1641-1654 (1999). See also cDNA Sequences AAF71545 (SEL-5A) and AAF71546 (SEL-5B).
	Method	Gene