F36H12.6 | SMap | S_parent | Sequence | F36H12
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| Chromosome | IV |
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Identity (5)
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Gene_info
| Gene_class | msp
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| | Phenotype | [C.elegansII] NMK. Encodes MSP (16kD); msp-113 cluster. [Ward et al. (1988); BA] |
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Structured_description
| Provisional_description | msp-52 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. |
Paper_evidence
| WBPaper00001023
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| | | | | | WBPaper00002143
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| | | | | | WBPaper00004591
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| | | | | | WBPaper00005670
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| | | | | Curator_confirmed | WBPerson324
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| | | | | Date_last_updated | 31 Mar 2005 00:00:00 |
| | | Concise_description | msp-52 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. |
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Molecular_info
| Corresponding_pseudogene | F36H12.6
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Corresponding_PCR_product (44)
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Corresponding_RNAi_reagent (44)
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Experimental_info (2)
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Reference (2)
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| Remark | pseudogene annotation in sequence. [sdm 05/00] |
| Method | Gene
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