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Gene: F36H12.7   

F36H12.7SMapS_parentSequenceF36H12
ChromosomeIV
Identity (5)
Gene_info Gene_classmsp
Phenotype[C.elegansII] NMK. Encodes MSP (16kD); msp-113 cluster. [Ward et al. (1988); BA]
GO_termGO:0005198 IEA Inferred_automatically
Structured_description Provisional_descriptionmsp-19 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-19 has a homolog in C. briggsae as predicted by the Wobble Aware Bulk Aligner (WABA); the msp gene family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. Paper_evidence (5)
Curator_confirmedWBPerson324
Date_last_updated26 Apr 2005 00:00:00
Concise_descriptionmsp-19 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-19 has a homolog in C. briggsae as predicted by the Wobble Aware Bulk Aligner (WABA); the msp gene family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.
Molecular_info Corresponding_CDSF36H12.7
Corresponding_proteinWP:CE02806
Corresponding_PCR_product (58)
Corresponding_RNAi_reagent Cenix:242-h2
sjj_F36H12.7
sjj_C04G2.4
mv_ZK354.4
sjj_ZK354.11
sjj_R05F9.8
Cenix:14-e7
sjj_C34F11.4
sjj_F32B6.6
Cenix:203-f6
Cenix:13-d1
sjj_R13H9.2
sjj_ZK354.1
sjj_C34F11.6
yk381d1
mv_C34F11.4
sjj_K08F4.8
sjj_F58A6.8
sjj_R05F9.3
mv_ZK1248.6
Cenix:16-c9
sjj_ZK546.6
Cenix:242-d2
mv_F36H12.7
mv_C34F11.6
sjj_K07F5.3
sjj_F26G1.7
Cenix:246-b8
sjj_ZK546.3
yk380e3
Cenix:13-c7
Cenix:242-c6
sjj_Y59E9_120.c
Cenix:206-e1
Cenix:243-c6
sjj_K07F5.1
mv_C09B9.6
mv_F26G1.7
Cenix:211-g4
sjj_R05F9.13
sjj_T13F2.11
Cenix:247-a1
Cenix:205-e12
Cenix:14-g4
Cenix:245-g4
mv_ZK546.6
sjj_Y4C6A.c
sjj_T13F2.10
Cenix:13-f11
sjj_K07F5.2
sjj_F09C12.7
Cenix:13-d7
yk384g8
sjj_R13H9.4
mv_R05F9.8
sjj_ZK1248.6
mv_Y59H11AM.d
sjj_C09B9.6
yk386a12
yk387c2
yk370d1
sjj_ZK354.5
mv_K05F1.2
mv_F32B6.6
Cenix:242-g2
Cenix:242-g7
sjj_ZK354.4
Experimental_info RNAi_result Cenix:242-h2
JA:F36H12.7
WB_RNAi_result (72)
Expr_patternExpr3417
Reference (4)
Remarkremoved from gmap IV 1.61 [jah/sdm 5/99
MethodGene