RNAiDB Tree View

Gene: F39C12.2

F39C12.2	SMap	S_parent	Sequence	F39C12
	Chromosome	X
	Identity (5)
	Gene_info	Gene_class	add
		GO_term (7)
		Structured_description	Provisional_description	add-1 encodes an ortholog of the cytoskeletal protein alpha-adducin (ADD1, OMIM:102680, mutations are associated with susceptibility to salt-sensitive essential hypertension); by homology, ADD-1 is predicted to be a cell membrane-associated protein that mediates localized changes in the cytoskeleton in response to activation of signal transduction cascades; as loss of add-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of ADD-1 in C. elegans development and/or behavior is not yet known.	Paper_evidence	WBPaper00004424
						WBPaper00005654
						WBPaper00010897
					Person_evidence	WBPerson1843
					Curator_confirmed	WBPerson1843
					Date_last_updated	17 Jun 2004 00:00:00
				Vertebrate adducin binds actin, calmodulin, and spectrin, and is a substrate for phosphorylation by protein kinases A and C.
				This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial.
			Concise_description	add-1 encodes an ortholog of the cytoskeletal protein alpha-adducin (ADD1, OMIM:102680, mutations are associated with susceptibility to salt-sensitive essential hypertension); by homology, ADD-1 is predicted to be a cell membrane-associated protein that mediates localized changes in the cytoskeleton in response to activation of signal transduction cascades; as loss of add-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of ADD-1 in C. elegans development and/or behavior is not yet known.
	Molecular_info (5)
	Experimental_info (5)
	Remark	Gene created based on email from [Blasiar D], [krb 020617]
	Method	Gene