Go to RNAiDB Home Adult Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie
 

Gene: F39H11.3   

F39H11.3EvidencePaper_evidenceWBPaper00004192
SMapS_parentSequenceF39H11
ChromosomeI
Identity (5)
Gene_info Gene_classcdk
Alleletm1238
GO_term GO:0004672 IEA Inferred_automatically
GO:0005524 IEA Inferred_automatically
GO:0006468 IEA Inferred_automatically
GO:0004674 IEA Inferred_automatically
Structured_description Provisional_description cdk-8 encodes a member of the cyclin-dependent serine/threonine protein kinase family orthologous to human CDK8 (OMIM:603184) which functions in transcriptional regulation with the positive regulatory factor cyclin C, is associated with the RNA polymerase II holoenzyme, and may regulate gene-specific activators; CDK-8 also contains a glutamine/asparagine-rich domain; loss of cdk-8 function via RNA-mediated interference (RNAi) results in sterility in the injected hermaphrodite, suggesting that in C. elegans, CDK-8 may play a role in germ-line development. Paper_evidence (11)
Person_evidenceWBPerson1843
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
Proteins bearing such domains can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain.
Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya.
Therefore, it is possible that this gene's protein product undergoes epigenetic control of protein activity, through heritable epigenetic modulation of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells.
It is important to note that this is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis.
Concise_descriptioncdk-8 encodes a member of the cyclin-dependent serine/threonine protein kinase family orthologous to human CDK8 (OMIM:603184) which functions in transcriptional regulation with the positive regulatory factor cyclin C, is associated with the RNA polymerase II holoenzyme, and may regulate gene-specific activators; CDK-8 also contains a glutamine/asparagine-rich domain; loss of cdk-8 function via RNA-mediated interference (RNAi) results in sterility in the injected hermaphrodite, suggesting that in C. elegans, CDK-8 may play a role in germ-line development.
Molecular_info (6)
Experimental_info RNAi_result (5)
WB_RNAi_result (6)
Reference WBPaper00004192
WBPaper00006530
WBPaper00010129
WBPaper00025388
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene