F39H11.3 | Evidence | Paper_evidence | WBPaper00004192
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| SMap | S_parent | Sequence | F39H11
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| Chromosome | I |
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Identity (5)
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Gene_info
| Gene_class | cdk
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| | Allele | tm1238
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| |
GO_term
| GO:0004672
| IEA
| Inferred_automatically |
| | | GO:0005524
| IEA
| Inferred_automatically |
| | | GO:0006468
| IEA
| Inferred_automatically |
| | | GO:0004674
| IEA
| Inferred_automatically |
| |
Structured_description
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Provisional_description
| cdk-8 encodes a member of the cyclin-dependent serine/threonine protein kinase family orthologous to human CDK8 (OMIM:603184) which functions in transcriptional regulation with the positive regulatory factor cyclin C, is associated with the RNA polymerase II holoenzyme, and may regulate gene-specific activators; CDK-8 also contains a glutamine/asparagine-rich domain; loss of cdk-8 function via RNA-mediated interference (RNAi) results in sterility in the injected hermaphrodite, suggesting that in C. elegans, CDK-8 may play a role in germ-line development. |
Paper_evidence (11)
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| | | | | Person_evidence | WBPerson1843
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| | | | | Curator_confirmed | WBPerson1843
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| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | | The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). |
| | | | Proteins bearing such domains can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. |
| | | | Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya. |
| | | | Therefore, it is possible that this gene's protein product undergoes epigenetic control of protein activity, through heritable epigenetic modulation of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. |
| | | | It is important to note that this is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. |
| | | Concise_description | cdk-8 encodes a member of the cyclin-dependent serine/threonine protein kinase family orthologous to human CDK8 (OMIM:603184) which functions in transcriptional regulation with the positive regulatory factor cyclin C, is associated with the RNA polymerase II holoenzyme, and may regulate gene-specific activators; CDK-8 also contains a glutamine/asparagine-rich domain; loss of cdk-8 function via RNA-mediated interference (RNAi) results in sterility in the injected hermaphrodite, suggesting that in C. elegans, CDK-8 may play a role in germ-line development. |
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Molecular_info (6)
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Experimental_info
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RNAi_result (5)
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WB_RNAi_result (6)
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Reference
| WBPaper00004192
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| | WBPaper00006530
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| | WBPaper00010129
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| | WBPaper00025388
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| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene
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