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Gene: F41C6.1   

F41C6.1SMapS_parentSequenceSUPERLINK_RWXL
ChromosomeX
Identity (5)
Gene_info Gene_classunc
Reference_allelee78
Allele (16)
Phenotype e78 : slight kinker poor backing large healthy slightly fat; dorsal extensions of DD and VD neurons grow in aberrant directions fail to reach dorsal cord; ventral cord disorganized etc. ES3 ME1. NA4 (e7 e181 ev400 (pka unc-106 : uncoordinated high frequency of phasmid axon displacement)).
See unc-6.
See also ev400, n102, n165, n593, n594
[C.elegansII] e78 : slight kinker, poor backing; large, healthy, slightly fat; dorsal extensions of DD and VD neurons grow in aberrant directions fail to reach dorsal cord; ventral cord disorganized; abnormal gonad arms, etc. ES3 ME1. OA>20: e7, e181, ev400 (pka unc-106,uncoordinated, high frequency of phasmid axon displacement), n593, n594 etc. Some alleles (rh202, rh204, rh402 etc.) defective only in dorsalward migrations. Null alleles defective in both dorsalward and ventralward migrations. See also unc-5, unc-40. Cloned: encodes extracellular matrix component, laminin-related at N-term, homologous to vertebrate netrins. [Ishii et al. 1992; NW]
Strain (10)
GO_term (7)
Structured_description Provisional_description unc-6 encodes a netrin orthologous to the human and mouse netrin-1 precursor proteins; UNC-6 functions as a guidance molecule that regulates the migrations of pioneer axons and mesodermal cells, such as the gonadal distal tip cell, along the dorsoventral axis; a secreted molecule, UNC-6 is expressed during embryogenesis by epidermoblasts and neurons; UNC-6 is involved in both attractive and repulsive interactions that are mediated by the UNC-40 and UNC-5 netrin receptors, respectively. Paper_evidence WBPaper00004938
WBPaper00005417
WBPaper00005809
WBPaper00023161
Person_evidenceWBPerson1843
Curator_confirmedWBPerson1843
Date_last_updated04 Jan 2005 00:00:00
The UNC-6 receptor in C. elegans is UNC-5.
UNC-6 stimulates the phophorylation of UNC-5 (on tyrosine) in vivo; UNC-5 tyrosine phosphorylation is reduced in unc-6 null mutants.
In mammals, phosphorylated UNC-5 (RCM) is bound by Shp2.
Concise_descriptionunc-6 encodes a netrin orthologous to the human and mouse netrin-1 precursor proteins; UNC-6 functions as a guidance molecule that regulates the migrations of pioneer axons and mesodermal cells, such as the gonadal distal tip cell, along the dorsoventral axis; a secreted molecule, UNC-6 is expressed during embryogenesis by epidermoblasts and neurons; UNC-6 is involved in both attractive and repulsive interactions that are mediated by the UNC-40 and UNC-5 netrin receptors, respectively.
Molecular_info (6)
Experimental_info (5)
Reference (263)
MethodGene