| | | [C.elegansII] e78 : slight kinker, poor backing; large, healthy, slightly fat; dorsal extensions of DD and VD neurons grow in aberrant directions fail to reach dorsal cord; ventral cord disorganized; abnormal gonad arms, etc. ES3 ME1. OA>20: e7, e181, ev400 (pka unc-106,uncoordinated, high frequency of phasmid axon displacement), n593, n594 etc. Some alleles (rh202, rh204, rh402 etc.) defective only in dorsalward migrations. Null alleles defective in both dorsalward and ventralward migrations. See also unc-5, unc-40. Cloned: encodes extracellular matrix component, laminin-related at N-term, homologous to vertebrate netrins. [Ishii et al. 1992; NW] |