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Gene: F43G6.1   

F43G6.1EvidencePerson_evidenceWBPerson338
SMapS_parentSequenceF43G6
ChromosomeII
Identity (5)
Gene_info Gene_classdna
AlleleuCE2-2038
Structured_description Provisional_descriptiondna-2 encodes the C. elegans ortholog of the yeast and vertebrate Dna2 replication helicases; by homology, DNA-2 is predicted to function as an endonuclease and an ATP-dependent helicase that is involved in DNA replication and repair; in C. elegans, DNA-2 activity is required maternally and zygotically to maintain normal rates of cell division and for proper germ-line, embryonic, and larval development; DNA-2 activity is temperature-sensitive: animals lacking DNA-2 at 16 degrees Celsius (C) are less severely affected than those at 20 or 25 degrees C; in the hermaphrodite gonad, DNA-2 localizes to nuclei of germ cells and developing oocytes, and expression continues in embryos up to the comma stage; DNA-2 then reappears at the L3 larval stage, and in L3 and L4 larvae is visible in the proliferating somatic cells of the uterus and spermatheca. Paper_evidence WBPaper00005745
WBPaper00006262
Curator_confirmedWBPerson1843
Date_last_updated07 Mar 2005 00:00:00
Concise_descriptiondna-2 encodes the C. elegans ortholog of the yeast and vertebrate Dna2 replication helicases; by homology, DNA-2 is predicted to function as an endonuclease and an ATP-dependent helicase that is involved in DNA replication and repair; in C. elegans, DNA-2 activity is required maternally and zygotically to maintain normal rates of cell division and for proper germ-line, embryonic, and larval development; DNA-2 activity is temperature-sensitive: animals lacking DNA-2 at 16 degrees Celsius (C) are less severely affected than those at 20 or 25 degrees C; in the hermaphrodite gonad, DNA-2 localizes to nuclei of germ cells and developing oocytes, and expression continues in embryos up to the comma stage; DNA-2 then reappears at the L3 larval stage, and in L3 and L4 larvae is visible in the proliferating somatic cells of the uterus and spermatheca.
Molecular_info (5)
Experimental_info RNAi_result Cenix:200-a6
JA:F43G6.1
PF:GL1_3A5
WB_RNAi_result JA:F43G6.1
Cenix:200-a6
PF:GL1_3A5
Expr_pattern Expr2568
Expr2569
InteractionWBInteraction0002248
Reference (6)
MethodGene