F45E10.1 | SMap | S_parent | Sequence | SUPERLINK_CB_II
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| Chromosome | II |
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Identity (5)
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Gene_info
| Gene_class | unc
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| | Reference_allele | e404
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Allele (11)
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Phenotype
| e404 : sluggish poor backing dumpyish somewhat Egl; males have abnormal bursal anatomy. ES2 ME0. NA4 (n152 n166 n569). |
| | | See also e2432, e2499, n152, n166, n569 |
| | | [C.elegansII] e404 : sluggish, poor backing, dumpyish; somewhat Egl; multiple defects in neuronal outgrowth, branching; also defects in excretory canal extension, gonad arm growth; males have abnormal bursal anatomy. ES2 ME0. OA>5: n152, n166, n569 (synergizes with sem-5(n177) to give strong Sem migration defect),e2432, e2499, etc. Null phenotype uncertain; some lethality in strong alleles. Cloned: multiple transcripts (different 5' ends); one encodes 1528 aa protein, predicted to bind actin, ATP/GTP; may interact with SEM-5. Transgene overexpression leads to extension of growth cones along a-p axis. [Hedgecock et al. 1987; Hekimi and Kershaw 1993; UG] |
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Strain (7)
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GO_term (15)
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Structured_description
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Provisional_description (10)
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| | | Concise_description | UNC-53 encodes at least five large (~1200-1600 residue) proteins, orthologous to human NAV1, NAV2/RAINB1 (OMIM:607026), and NAV3, and homologous to Drosophila CG10662; UNC-53 proteins are required for anteroposterior guidance of migrating cells and axons, and for egg-laying, correct backward locomotion, full body size, and male mating; UNC-53 proteins vary in their N-terminal regions but share common C-terminal sequences with an AAA-ATPase domain; UNC-71 binds B0336.6 in a yeast two-hybrid screen, and interacts both physically and genetically with SEM-5; unc-53 is expressed in those cells requiring it, suggesting that its function is cell-autonomous; overexpression of unc-53 induces excess cellular outgrowth. |
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Molecular_info (5)
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Experimental_info
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RNAi_result
| Cenix:148-h1
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| | | JA:F45E10.1
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WB_RNAi_result
| JA:F45E10.1
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| | | Cenix:148-h1
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Expr_pattern
| Expr1918
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| | | Expr1919
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| | | Expr1920
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Interaction (5)
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Reference (63)
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| Method | Gene
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