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Gene: F45E10.1   

F45E10.1SMapS_parentSequenceSUPERLINK_CB_II
ChromosomeII
Identity (5)
Gene_info Gene_classunc
Reference_allelee404
Allele (11)
Phenotype e404 : sluggish poor backing dumpyish somewhat Egl; males have abnormal bursal anatomy. ES2 ME0. NA4 (n152 n166 n569).
See also e2432, e2499, n152, n166, n569
[C.elegansII] e404 : sluggish, poor backing, dumpyish; somewhat Egl; multiple defects in neuronal outgrowth, branching; also defects in excretory canal extension, gonad arm growth; males have abnormal bursal anatomy. ES2 ME0. OA>5: n152, n166, n569 (synergizes with sem-5(n177) to give strong Sem migration defect),e2432, e2499, etc. Null phenotype uncertain; some lethality in strong alleles. Cloned: multiple transcripts (different 5' ends); one encodes 1528 aa protein, predicted to bind actin, ATP/GTP; may interact with SEM-5. Transgene overexpression leads to extension of growth cones along a-p axis. [Hedgecock et al. 1987; Hekimi and Kershaw 1993; UG]
Strain (7)
GO_term (15)
Structured_description Provisional_description (10)
Concise_descriptionUNC-53 encodes at least five large (~1200-1600 residue) proteins, orthologous to human NAV1, NAV2/RAINB1 (OMIM:607026), and NAV3, and homologous to Drosophila CG10662; UNC-53 proteins are required for anteroposterior guidance of migrating cells and axons, and for egg-laying, correct backward locomotion, full body size, and male mating; UNC-53 proteins vary in their N-terminal regions but share common C-terminal sequences with an AAA-ATPase domain; UNC-71 binds B0336.6 in a yeast two-hybrid screen, and interacts both physically and genetically with SEM-5; unc-53 is expressed in those cells requiring it, suggesting that its function is cell-autonomous; overexpression of unc-53 induces excess cellular outgrowth.
Molecular_info (5)
Experimental_info RNAi_result Cenix:148-h1
JA:F45E10.1
WB_RNAi_result JA:F45E10.1
Cenix:148-h1
Expr_pattern Expr1918
Expr1919
Expr1920
Interaction (5)
Reference (63)
MethodGene