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Gene: F47G6.1   

F47G6.1SMapS_parentSequenceF47G6
ChromosomeI
Identity (5)
Gene_info Gene_classdyb
Allele (7)
Strain (5)
Structured_description Provisional_description The dyb-1 gene encodes a homolog of mammalian alpha-dystrobrevin (DTNA; OMIM:601239), mutation of which can lead to left ventricular noncompaction with congenital heart defects. Paper_evidence WBPaper00004614
WBPaper00005175
Person_evidenceWBPerson567
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
More generally, loss of alpha-dystrobrevin is observed in several forms of inherited muscular dystrophy, and may be the key pathogenic event in all of them.
DYB-1 protein binds DYS-1 both in yeast two-hybrid assays and in vitro.
Partially deleted forms of DYB-1 lacking the second helix of the DYB-1 coiled-coil domain abolished binding of DYB-1 to DYS-1, and also abolished the ability of a dyb-1 transgene to rescue a dyb-1 mutation in vivo.
Concise_descriptionThe dyb-1 gene encodes a homolog of mammalian alpha-dystrobrevin (DTNA; OMIM:601239), mutation of which can lead to left ventricular noncompaction with congenital heart defects.
Molecular_info (5)
Experimental_info (6)
Reference (13)
MethodGene