F47G6.1 | SMap | S_parent | Sequence | F47G6
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| Chromosome | I |
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Identity (5)
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Gene_info
| Gene_class | dyb
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Allele (7)
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Strain (5)
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Structured_description
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Provisional_description
| The dyb-1 gene encodes a homolog of mammalian alpha-dystrobrevin (DTNA; OMIM:601239), mutation of which can lead to left ventricular noncompaction with congenital heart defects. |
Paper_evidence
| WBPaper00004614
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| | | | | | WBPaper00005175
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| | | | | Person_evidence | WBPerson567
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| | | | | Curator_confirmed | WBPerson567
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| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | | More generally, loss of alpha-dystrobrevin is observed in several forms of inherited muscular dystrophy, and may be the key pathogenic event in all of them. |
| | | | DYB-1 protein binds DYS-1 both in yeast two-hybrid assays and in vitro. |
| | | | Partially deleted forms of DYB-1 lacking the second helix of the DYB-1 coiled-coil domain abolished binding of DYB-1 to DYS-1, and also abolished the ability of a dyb-1 transgene to rescue a dyb-1 mutation in vivo. |
| | | Concise_description | The dyb-1 gene encodes a homolog of mammalian alpha-dystrobrevin (DTNA; OMIM:601239), mutation of which can lead to left ventricular noncompaction with congenital heart defects. |
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Molecular_info (5)
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Experimental_info (6)
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Reference (13)
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| Method | Gene
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