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Gene: F48E8.1   

F48E8.1SMapS_parentSequenceF48E8
ChromosomeIII
Identity (5)
Gene_info Gene_classlon
Reference_allelee185
Allele (14)
Phenotype See also n1130
[C.elegansII] e185 : about 50% longer than wildtype at all stages, markedly tapering tail and head; low penetrance tendency to form constriction behind head, may result in auto-decapitation. Eggs elongated.ES3. Male bursa elongated ME0. OA5: e43, e1820, n1130 etc. (some have stronger Lon phenotype than e185, all show some decapitation). [Brenner 1974; MT]
Strain (18)
GO_termGO:0005576 IEA Inferred_automatically
Structured_description Provisional_description The lon-1 gene encodes a protein belonging to the PR-protein superfamily that is a target of DBL-1 (TGF-beta) signaling, and that regulates polyploidization and body length.Paper_evidenceWBPaper00005152
Person_evidenceWBPerson567
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
PR-proteins are found in yeast, plants, insects, and humans.
The lon-1 gene is downregulated in worms overexpressing DBL-1 that are 16% longer than wild type; lon-1(RNAi) or lon-1 mutant worms show a phenotype similar to that of excess DBL-1.
Endoreduplication of hypodermal nuclei is increased 19% in lon-1(e185) animals.
PR-proteins are found in yeast, plants, insects, and humans; the conservation suggests that LON-1 might represent a novel, but general downstream component of TGF-beta signalling.
lon-1 is epistatic to dbl-1.
Concise_descriptionThe lon-1 gene encodes a protein belonging to the PR-protein superfamily that is a target of DBL-1 (TGF-beta) signaling, and that regulates polyploidization and body length.
Molecular_info Corresponding_CDS (3)
Corresponding_protein WP:CE01953
WP:CE29046
WP:CE30996
Corresponding_PCR_product smd_F48E8.1
sjj_F48E8.1
Corresponding_RNAi_reagent (6)
Experimental_info (6)
Reference (63)
RemarkSequence connection from [Morita Y, Leroi AM, Ueno N], 02/06/11 krb.
MethodGene