F48E8.1 | SMap | S_parent | Sequence | F48E8
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| Chromosome | III |
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Identity (5)
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Gene_info
| Gene_class | lon
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| | Reference_allele | e185
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Allele (14)
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Phenotype
| See also n1130 |
| | | [C.elegansII] e185 : about 50% longer than wildtype at all stages, markedly tapering tail and head; low penetrance tendency to form constriction behind head, may result in auto-decapitation. Eggs elongated.ES3. Male bursa elongated ME0. OA5: e43, e1820, n1130 etc. (some have stronger Lon phenotype than e185, all show some decapitation). [Brenner 1974; MT] |
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Strain (18)
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| | GO_term | GO:0005576
| IEA
| Inferred_automatically |
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Structured_description
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Provisional_description
| The lon-1 gene encodes a protein belonging to the PR-protein superfamily that is a target of DBL-1 (TGF-beta) signaling, and that regulates polyploidization and body length. | Paper_evidence | WBPaper00005152
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| | | | | Person_evidence | WBPerson567
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| | | | | Curator_confirmed | WBPerson567
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| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | | PR-proteins are found in yeast, plants, insects, and humans. |
| | | | The lon-1 gene is downregulated in worms overexpressing DBL-1 that are 16% longer than wild type; lon-1(RNAi) or lon-1 mutant worms show a phenotype similar to that of excess DBL-1. |
| | | | Endoreduplication of hypodermal nuclei is increased 19% in lon-1(e185) animals. |
| | | | PR-proteins are found in yeast, plants, insects, and humans; the conservation suggests that LON-1 might represent a novel, but general downstream component of TGF-beta signalling. |
| | | | lon-1 is epistatic to dbl-1. |
| | | Concise_description | The lon-1 gene encodes a protein belonging to the PR-protein superfamily that is a target of DBL-1 (TGF-beta) signaling, and that regulates polyploidization and body length. |
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Molecular_info
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Corresponding_CDS (3)
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Corresponding_protein (3)
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Corresponding_PCR_product
| smd_F48E8.1
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| | | sjj_F48E8.1
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Corresponding_RNAi_reagent (6)
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Experimental_info (6)
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Reference (63)
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| Remark | Sequence connection from [Morita Y, Leroi AM, Ueno N], 02/06/11 krb. |
| Method | Gene
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