RNAiDB Tree View

Gene: F48E8.5

F48E8.5	Evidence	Author_evidence	Ogura K-i
	SMap	S_parent	Sequence	F48E8
	Chromosome	III
	Identity (5)
	Gene_info	Gene_class	paa
		GO_term	GO:0005488	IEA	Inferred_automatically
		Contained_in_operon	CEOP3304
		Structured_description	Provisional_description	paa-1 encodes a homolog of PR65, the structural subunit of protein phosphatase 2A (PP2A); PAA-1 protein is bound by SMG-5; PAA-1 is required in mass RNAi assays for embryonic viability, fertility, and cuticular integrity.	Paper_evidence	WBPaper00005723
						WBPaper00012850
					Person_evidence	WBPerson567
					Curator_confirmed	WBPerson567
					Date_last_updated	17 Jun 2004 00:00:00
				SMG-5 interacts with PAA-1 in yeast two-hybrid experiments, and coimmunoprecipitates with PP2A and SMG-2.
				Eukaryotic PP2As are a family of ubiquitous, abundant, Ser/Thr protein phosphatases, usually heterotrimeric, and usually containing: a 36 kDa catalytic subunit (PP2AC); a 65 kDa structural subunit that scaffolds assembly of active enzyme (PR65); and one of several, varying B-type regulatory subunits.
				B subunits are thought to regulate activity, subcellular localization and substrate specificity of the catalytic complex.
			Concise_description	paa-1 encodes a homolog of PR65, the structural subunit of protein phosphatase 2A (PP2A); PAA-1 protein is bound by SMG-5; PAA-1 is required in mass RNAi assays for embryonic viability, fertility, and cuticular integrity.
	Molecular_info (5)
	Experimental_info	RNAi_result (6)
		WB_RNAi_result (7)
		Expr_pattern	Expr5542
		Y2H_bait	Y2H011504
	Reference (4)
	Method	Gene