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Gene: F53G12.5   

F53G12.5SMapS_parentSequenceF53G12
ChromosomeI
Identity (5)
Gene_info Gene_classmex
Allele (15)
Phenotype [Draper BW] Maternal effect lethal mutations which results in the production of excess muscle. The excess muscle is derived from the anterior blastomere AB of the two cell stage embryo.
[C.elegansII] zu142 : maternal effect lethal mutations which results in the production of excess muscle. The excess muscle is derived from the anterior blastomere AB of the two cell stage embryo. OA8: zu155, zu203, zu205, zu208, zu211, etc. Cloned: encodes novel predicted protein with two KH domains. mRNA accumulates at anterior pole of zygote after fertilization. [JJ]
Strain JJ478
JJ1014
GO_term (9)
Structured_description Provisional_description mex-3 encodes two KH domain-containing RNA binding proteins; in the early embryo, maternally provided MEX-3 is required for specifying the identities of the anterior AB blastomere and its descendants, as well as for the identity of the P3 blastomere and proper segregation of the germline P granules; mex-3 mRNA is distributed uniformly in the syncytial core of the adult distal gonad, mature oocytes, and early 1-cell stage embryos, but then becomes more prominent in the AB blastomere and its daughters by the 4-cell stage after which it is rapidly degraded save for the D and P4 blastomeres; MEX-3 protein is also detected uniformly in the cytoplasm of oocytes and 1-cell stage embryos, but like the mRNA, becomes more abundant in AB and its daughters at the 2- and 4-cell stages, respectively, before disappearing; MEX-3 is also detected in association with P granules from the 2-cell stage until the late stages of embryogenesis.Paper_evidenceWBPaper00002572
Curator_confirmedWBPerson1843
Date_last_updated20 Jun 2005 00:00:00
mex-3 encodes two KH domain-containing RNA binding proteins; MEX-3 is required maternally in the early embryo for specifying the identities of the anterior AB blastomere and its descendants, as well as for the identity of the P3 blastomere and proper segregation of the germline P granules; mex-3 mRNA is distributed uniformly in the syncytial core of the adult distal gonad, mature oocytes, and early 1-cell stage embryos, but then becomes more prominent in the AB blastomere and its daughters by the 4-cell stage after which it is rapidly degraded save for the D and P4 blastomeres; MEX-3 protein is also detected uniformly in the cytoplasm of oocytes and 1-cell stage embryos, but like the mRNA, becomes more abundant in AB and its daughters at the 2- and 4-cell stages, respectively, before disappearing; MEX-3 is also detected in association with P granules from the 2-cell stage until the late stages of embryogenesis.Paper_evidenceWBPaper00002572
Person_evidenceWBPerson1843
Concise_description mex-3 encodes two KH domain-containing RNA binding proteins; in the early embryo, maternally provided MEX-3 is required for specifying the identities of the anterior AB blastomere and its descendants, as well as for the identity of the P3 blastomere and proper segregation of the germline P granules; mex-3 mRNA is distributed uniformly in the syncytial core of the adult distal gonad, mature oocytes, and early 1-cell stage embryos, but then becomes more prominent in the AB blastomere and its daughters by the 4-cell stage after which it is rapidly degraded save for the D and P4 blastomeres; MEX-3 protein is also detected uniformly in the cytoplasm of oocytes and 1-cell stage embryos, but like the mRNA, becomes more abundant in AB and its daughters at the 2- and 4-cell stages, respectively, before disappearing; MEX-3 is also detected in association with P granules from the 2-cell stage until the late stages of embryogenesis.
mex-3 encodes two KH domain-containing RNA binding proteins; MEX-3 is required maternally in the early embryo for specifying the identities of the anterior AB blastomere and its descendants, as well as for the identity of the P3 blastomere and proper segregation of the germline P granules; mex-3 mRNA is distributed uniformly in the syncytial core of the adult distal gonad, mature oocytes, and early 1-cell stage embryos, but then becomes more prominent in the AB blastomere and its daughters by the 4-cell stage after which it is rapidly degraded save for the D and P4 blastomeres; MEX-3 protein is also detected uniformly in the cytoplasm of oocytes and 1-cell stage embryos, but like the mRNA, becomes more abundant in AB and its daughters at the 2- and 4-cell stages, respectively, before disappearing; MEX-3 is also detected in association with P granules from the 2-cell stage until the late stages of embryogenesis.
Molecular_info (5)
Experimental_info RNAi_result JA:F53G12.5
Simmer:F53G12.5:Screen_A
Simmer:F53G12.5:Screen_B
Cenix:75-f1
WB_RNAi_result (5)
Expr_pattern Expr573
Expr697
Gene_regulation Trans_regulatorpmid15201219_pal-1.b
Trans_targetpmid15201219_mex-3
Y2H_target Y2H010878
Y2H011285
Interaction (12)
Reference (58)
MethodGene