RNAiDB Tree View

Gene: F54A5.3

F54A5.3	SMap	S_parent	Sequence	F54A5
	Chromosome	I
	Identity (5)
	Gene_info	Allele	ok198
			tm1729
		Structured_description	Provisional_description	F54A5.3 encodes four proteins by multiple splicing, three of which are rather small (52-81 residues); however, one isoform (F54A5.3A, 316 residues) is a ortholog of vertebrate Shc proteins (e.g., p52/p46SHC and p66SHC); like its orthologs, F54A5.3A has a PTB and an SH2 domain in N- to C-terminal order; F54A5.3 has no obvious function in mass RNAi assays, but might be involved in RAS signal transduction or regulation of apoptosis.	Paper_evidence	WBPaper00004558
						WBPaper00004651
					Person_evidence	WBPerson567
					Curator_confirmed	WBPerson567
					Date_last_updated	17 Jun 2004 00:00:00
				Co-occurence of one PTB and one SH2 domain within a single protein is rare, and when it does occur, appears to define two unrelated proteins: tensin (in the N- to C-terminal order of SH2 to PTB) and Shc (in the PTB to SH2 order).
				Unlike vertebrate SHC proteins, F54A5.3 proteins lack a CH2 region, and thus are not predicted to mediate responses to oxidative stress via serine or threonine phosphorylation; this function appears to have evolved relatively recently in vertebrate SHC proteins.
			Concise_description	F54A5.3 encodes four proteins by multiple splicing, three of which are rather small (52-81 residues); however, one isoform (F54A5.3A, 316 residues) is a ortholog of vertebrate Shc proteins (e.g., p52/p46SHC and p66SHC); like its orthologs, F54A5.3A has a PTB and an SH2 domain in N- to C-terminal order; F54A5.3 has no obvious function in mass RNAi assays, but might be involved in RAS signal transduction or regulation of apoptosis.
	Molecular_info (5)
	Experimental_info (5)
	Method	Gene