| | | [C.elegansII] e936 : coiler, small and dumpyish, inactive; commissures often on wrong side; variable defects in axon growth and fasciculation;occasional lineage defects; reduced Z migration. Male copulatory spicules short and crumpled. Synergizes with sem-5(n1779) to give Sem migration defect.ES3 ME0. OA>3: rh40, ev454::Tc1,e936je3 (intragenic change, recessive lethal and dominant suppressor of e936). See also sup-39. Cloned: 7.7 and 7.3 kb transcripts, encodes >200 kD protein related to rho-type guanine nucleotide exchange factors, yeast CDC24. [McIntire et al. 1992; Garriga and Stern 1994; NJ; JW; NW] |
| | | Concise_description | The unc-73 gene encodes a guanine nucleotide exchange factor (GNEF) similar to the Trio protein; UNC-73 is required for vulval morphogenesis, for the migration of QL, QR, and hypodermal P cells, the commisure outgrowth of D type motoneurons, and amphid axon outgrowth; UNC-73 has GNEF activity for both CED-10 and MIG-2 in vitro; the requirement for UNC-73 in P cell migration can be suppressed by transgenic overexpression of rho-1; UNC-73 activates several small GTPases: RHO-1 in P cell migration, and both CED-10 and MIG-2 in vulval morphogenesis, P cell migration, and axon outgrowth. |
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