RNAiDB Tree View

Gene: F56G4.2

F56G4.2	SMap	S_parent	Sequence	F56G4
	Chromosome	I
	Identity (5)
	Gene_info	Gene_class	pes
		Phenotype	[C.elegansII] NMK. Resident gene encodes novel protein.pes-2:lacZ expressed in many nuclei from 14-cell stage (not C, D or P4), after 200 min only in ABn, especially hypodermis. Clone UL#100G5, cosmid F56G4. [Young and Hope 1993; UL]
		Structured_description	Provisional_description	pes-2 encodes a protein containing a predicted signal sequence and an F-box, a motif believed to mediate protein-protein interactions either with homologs of yeast Skp1p or with other proteins; pes-2 was identified in two different molecular screens, a promoter-trapping screen and a screen for genes that are preferentially transcribed in pre-gastrulation embryos; by homology, pes-2 is predicted to function in ubiquitin-proteasome mediated protein degradation; pes-2 may also play a role in lifespan determination, as its expression is downregulated in young adult worms containing loss-of-function mutations in the daf-2 insulin/IGF-1 receptor, and loss of pes-2 function via RNA-mediated interference (RNAi) can enhance animal survival rates; pes-2 expression is first detected in 4- to 8-cell stage embryos, continues in early embryogenesis in cells from the AB, MS, and E founder cell lineages, and in later embryogenesis is becomes restricted to hypodermal cells; expression in larvae and adults has not yet been reported.	Paper_evidence	WBPaper00002526
						WBPaper00004540
						WBPaper00005654
						WBPaper00005976
					Person_evidence	WBPerson1843
					Curator_confirmed	WBPerson1843
					Date_last_updated	17 Jun 2004 00:00:00
			Concise_description	pes-2 encodes a protein containing a predicted signal sequence and an F-box, a motif believed to mediate protein-protein interactions either with homologs of yeast Skp1p or with other proteins; pes-2 was identified in two different molecular screens, a promoter-trapping screen and a screen for genes that are preferentially transcribed in pre-gastrulation embryos; by homology, pes-2 is predicted to function in ubiquitin-proteasome mediated protein degradation; pes-2 may also play a role in lifespan determination, as its expression is downregulated in young adult worms containing loss-of-function mutations in the daf-2 insulin/IGF-1 receptor, and loss of pes-2 function via RNA-mediated interference (RNAi) can enhance animal survival rates; pes-2 expression is first detected in 4- to 8-cell stage embryos, continues in early embryogenesis in cells from the AB, MS, and E founder cell lineages, and in later embryogenesis is becomes restricted to hypodermal cells; expression in larvae and adults has not yet been reported.
	Molecular_info (5)
	Experimental_info	RNAi_result	Cenix:197-a10
			Cenix:197-b10
			JA:F56G4.2
			PF:GL1_1C12
		WB_RNAi_result (5)
		Expr_pattern	Expr46
		Interaction	WBInteraction0003209
	Reference (6)
	Method	Gene