F57F5.5 | SMap | S_parent | Sequence | SUPERLINK_CB_V
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| Chromosome | V |
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Identity (5)
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Gene_info
| Gene_class | pkc
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Allele (10)
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Phenotype
| [C.elegansII] NMK CR#PKC1A sofar??? |
| | | [C.elegansII] VNMK. Not located on physical map. Encodes kinases related to protein kinase C (PKC1A and PKC1B). Transcript from proximal promoter encodes 707aa PKC1B, antibody stains cell bodies and processes of ~75 sensory neurons. Transcription from distal promoter yields kup-1, PKC1A (SL2 transpliced, 763 aa (additional 56aa at N-term of PKC1B). B:A ratio ~40 in early development, unity in adults. [Land et al. 1994a; Land et al. 1994b; CR] |
| | Strain | RB781
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GO_term (10)
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| | Contained_in_operon | CEOP5312
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Structured_description
| Provisional_description | pkc-1 encodes a serine/threonine protein kinase that is orthologous to mammalian protein kinase C epsilon (PRKCE), a member of the nPKC subgroup of the protein kinase C superfamily; together with UNC-13, PKC-1 may act downstream of goa-1 to modulate phorbol ester-induced stimulation of acetylcholine release at NMJs; PKC-1 positively regulates locomotion, and affects thermotaxis and chemotaxis together with kin-11; PKC-1 is required for regulating several behaviors including sensation of volatile and soluble compounds, osmolarity, and temperature (thermosensation); PKC-1 is also required for phorbolester-induced stimulation of acetylcholine release at neuromuscular junctions; PKC-1 localizes to the processes and cell bodies of approximately 75 sensory neurons and interneurons, and pkc-1 mRNA is detectable at varying levels during larval and adult stages. |
Paper_evidence (5)
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| | | | | Person_evidence | WBPerson48
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| | | | | Curator_confirmed | WBPerson48
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| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Concise_description | pkc-1 encodes a serine/threonine protein kinase that is orthologous to mammalian protein kinase C epsilon (PRKCE), a member of the nPKC subgroup of the protein kinase C superfamily; together with UNC-13, PKC-1 may act downstream of goa-1 to modulate phorbol ester-induced stimulation of acetylcholine release at NMJs; PKC-1 positively regulates locomotion, and affects thermotaxis and chemotaxis together with kin-11; PKC-1 is required for regulating several behaviors including sensation of volatile and soluble compounds, osmolarity, and temperature (thermosensation); PKC-1 is also required for phorbolester-induced stimulation of acetylcholine release at neuromuscular junctions; PKC-1 localizes to the processes and cell bodies of approximately 75 sensory neurons and interneurons, and pkc-1 mRNA is detectable at varying levels during larval and adult stages. |
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Molecular_info (7)
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Experimental_info
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RNAi_result (12)
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WB_RNAi_result (13)
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Expr_pattern (5)
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Reference (15)
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Remark
| Map is V. |
| | Sequence connection updated to F57F5.5 as previous sequence (F10C2.1) was merged into F57F5.5. [020620 krb] |
| | clone CR#PKC1A appears to be spuriously associated with F48E8 on LGIII [jah 040303][030407 ck1] |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene
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