Gene: F58A4.3
F58A4.3 | SMap | S_parent | Sequence | F58A4 | |||||
---|---|---|---|---|---|---|---|---|---|
Chromosome | III | ||||||||
Identity | Version | 1 | |||||||
Name (7) | |||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Gene_class | hcp | |||||||
GO_term (10) | |||||||||
Structured_description | Provisional_description | The hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos. | Paper_evidence | WBPaper00004736 | |||||
Person_evidence | WBPerson567 | ||||||||
Curator_confirmed | WBPerson567 | ||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Concise_description | The hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos. | ||||||||
Molecular_info | Corresponding_CDS | F58A4.3 | |||||||
Corresponding_protein | WP:CE00219 | ||||||||
KOG | KOG1745 | ||||||||
Corresponding_PCR_product | smd_F54C8.2 | ||||||||
smd_F54C8.2:2 | |||||||||
sjj_F58A4.3 | |||||||||
sjj_F54C8.2 | |||||||||
Corresponding_RNAi_reagent (12) | |||||||||
Experimental_info | RNAi_result (5) | ||||||||
WB_RNAi_result | TH:335f3 | ||||||||
[cgc4544]:hcp-3 | |||||||||
[cgc4736]:hcp-3 | |||||||||
JA:F54C8.2 | |||||||||
JA:F58A4.3 | |||||||||
[cgc5322]:hcp-3 | |||||||||
[cgc5264]:hcp-3 | |||||||||
Simmer:F54C8.2 | |||||||||
Simmer:F58A4.3 | |||||||||
MV_SV:mv_G_YK2579_1 | |||||||||
Cenix:322-d11 | |||||||||
Cenix:335-f3 | |||||||||
Cenix:175-b7 | |||||||||
Expr_pattern (5) | |||||||||
Gene_regulation | Trans_regulator | cgc4735_hcp-1_b | |||||||
cgc4735_hcp-4 | |||||||||
Trans_target | cgc4735_hcp-3 | ||||||||
Y2H_target | Y2H007532 | ||||||||
Reference (14) | |||||||||
Remark | Sequence connection from [Moore LL, Roth MB]. krb 13/11/01 | ||||||||
Method | Gene |