Gene: F58A4.3
F58A4.3 | SMap | S_parent | Sequence | F58A4 | |||||
---|---|---|---|---|---|---|---|---|---|
Chromosome | III | ||||||||
Identity | Version | 1 | |||||||
Name | CGC_name | hcp-3 | Person_evidence | WBPerson537 | |||||
Sequence_name | F58A4.3 | ||||||||
Molecular_name | F58A4.3 | ||||||||
WP:CE00219 | |||||||||
CE00219 | |||||||||
Other_name | NM_066727 | Inferred_automatically | |||||||
Date_last_updated | 15 Apr 2005 00:00:00 | WS142 | |||||||
Public_name | hcp-3 | ||||||||
Synonym (5) | |||||||||
WBGeneID | WBGene00001831 | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Gene_class | hcp | |||||||
GO_term (10) | |||||||||
Structured_description | Provisional_description | The hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos. | Paper_evidence | WBPaper00004736 | |||||
Person_evidence | WBPerson567 | ||||||||
Curator_confirmed | WBPerson567 | ||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Concise_description | The hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos. | ||||||||
Molecular_info | Corresponding_CDS | F58A4.3 | |||||||
Corresponding_protein | WP:CE00219 | ||||||||
KOG | KOG1745 | ||||||||
Corresponding_PCR_product | smd_F54C8.2 | ||||||||
smd_F54C8.2:2 | |||||||||
sjj_F58A4.3 | |||||||||
sjj_F54C8.2 | |||||||||
Corresponding_RNAi_reagent (12) | |||||||||
Experimental_info | RNAi_result | Cenix:175-b7 | |||||||
Cenix:335-f3 | |||||||||
JA:F58A4.3 | |||||||||
Simmer:F58A4.3 | |||||||||
TH:335f3 | |||||||||
WB_RNAi_result (13) | |||||||||
Expr_pattern (5) | |||||||||
Gene_regulation | Trans_regulator | cgc4735_hcp-1_b | |||||||
cgc4735_hcp-4 | |||||||||
Trans_target | cgc4735_hcp-3 | ||||||||
Y2H_target | Y2H007532 | ||||||||
Reference (14) | |||||||||
Remark | Sequence connection from [Moore LL, Roth MB]. krb 13/11/01 | ||||||||
Method | Gene |