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Gene: F58A4.3   

F58A4.3SMapS_parentSequenceF58A4
ChromosomeIII
Identity (5)
Gene_info Gene_classhcp
GO_term (10)
Structured_description Provisional_descriptionThe hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos.Paper_evidenceWBPaper00004736
Person_evidenceWBPerson567
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
Concise_descriptionThe hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos.
Molecular_info (5)
Experimental_info RNAi_result Cenix:175-b7
Cenix:335-f3
JA:F58A4.3
Simmer:F58A4.3
TH:335f3
WB_RNAi_result (13)
Expr_pattern (5)
Gene_regulation (2)
Y2H_targetY2H007532
Reference (14)
RemarkSequence connection from [Moore LL, Roth MB]. krb 13/11/01
MethodGene