F58A4.3 | SMap | S_parent | Sequence | F58A4
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| Chromosome | III |
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Identity (5)
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Gene_info
| Gene_class | hcp
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GO_term (10)
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Structured_description
| Provisional_description | The hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos. | Paper_evidence | WBPaper00004736
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| | | | | Person_evidence | WBPerson567
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| | | | | Curator_confirmed | WBPerson567
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| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Concise_description | The hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos. |
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Molecular_info
| Corresponding_CDS | F58A4.3
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| | Corresponding_protein | WP:CE00219
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| | KOG | KOG1745
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Corresponding_PCR_product
| smd_F54C8.2
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| | | smd_F54C8.2:2
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| | | sjj_F58A4.3
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| | | sjj_F54C8.2
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Corresponding_RNAi_reagent (12)
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Experimental_info (5)
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Reference (14)
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| Remark | Sequence connection from [Moore LL, Roth MB]. krb 13/11/01 |
| Method | Gene
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