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Gene: F58A4.3   

F58A4.3SMapS_parentSequenceF58A4
ChromosomeIII
Identity (5)
Gene_info Gene_classhcp
GO_term GO:0000070 IMP Paper_evidenceWBPaper00003702
Curator_confirmedWBPerson324
GO:0000069 IMP Paper_evidenceWBPaper00003702
Curator_confirmedWBPerson324
GO:0007052 IMP Paper_evidenceWBPaper00003702
Curator_confirmedWBPerson324
GO:0000779 IDA (2)
GO:0005634 IDA (2)
IEA Inferred_automatically
GO:0005515 TAS Paper_evidenceWBPaper00003702
Curator_confirmedWBPerson324
GO:0003677 IEA Inferred_automatically
GO:0006334 IEA Inferred_automatically
GO:0007001 IEA Inferred_automatically
GO:0000786 IEA Inferred_automatically
Structured_description Provisional_descriptionThe hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos.Paper_evidenceWBPaper00004736
Person_evidenceWBPerson567
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
Concise_descriptionThe hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos.
Molecular_info Corresponding_CDSF58A4.3
Corresponding_proteinWP:CE00219
KOGKOG1745
Corresponding_PCR_product smd_F54C8.2
smd_F54C8.2:2
sjj_F58A4.3
sjj_F54C8.2
Corresponding_RNAi_reagent (12)
Experimental_info RNAi_result (5)
WB_RNAi_result (13)
Expr_pattern (5)
Gene_regulation Trans_regulator cgc4735_hcp-1_b
cgc4735_hcp-4
Trans_targetcgc4735_hcp-3
Y2H_targetY2H007532
Reference (14)
RemarkSequence connection from [Moore LL, Roth MB]. krb 13/11/01
MethodGene