F58A4.3 | SMap | S_parent | Sequence | F58A4
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| Chromosome | III |
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Identity
| Version | 1 |
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Name (7)
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| | Species | Caenorhabditis elegans
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| | History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971
| Event | Imported | Initial conversion from geneace |
| | Status | Live |
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Gene_info
| Gene_class | hcp
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GO_term (10)
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Structured_description
| Provisional_description | The hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos. | Paper_evidence | WBPaper00004736
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| | | | | Person_evidence | WBPerson567
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| | | | | Curator_confirmed | WBPerson567
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| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Concise_description | The hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos. |
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Molecular_info (5)
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Experimental_info
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RNAi_result (5)
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WB_RNAi_result (13)
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Expr_pattern (5)
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Gene_regulation (2)
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| | Y2H_target | Y2H007532
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Reference (14)
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| Remark | Sequence connection from [Moore LL, Roth MB]. krb 13/11/01 |
| Method | Gene
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