Gene: F58A4.3
F58A4.3 | SMap | S_parent | Sequence | F58A4 | |||||
---|---|---|---|---|---|---|---|---|---|
Chromosome | III | ||||||||
Identity | Version | 1 | |||||||
Name (7) | |||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Gene_class | hcp | |||||||
GO_term | GO:0000070 | IMP | Paper_evidence | WBPaper00003702 | |||||
Curator_confirmed | WBPerson324 | ||||||||
GO:0000069 | IMP | Paper_evidence | WBPaper00003702 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
GO:0007052 | IMP | Paper_evidence | WBPaper00003702 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
GO:0000779 | IDA | Paper_evidence | WBPaper00003702 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
GO:0005634 | IDA | Paper_evidence | WBPaper00003702 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
IEA | Inferred_automatically | ||||||||
GO:0005515 | TAS (2) | ||||||||
GO:0003677 | IEA | Inferred_automatically | |||||||
GO:0006334 | IEA | Inferred_automatically | |||||||
GO:0007001 | IEA | Inferred_automatically | |||||||
GO:0000786 | IEA | Inferred_automatically | |||||||
Structured_description | Provisional_description | The hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos. | Paper_evidence | WBPaper00004736 | |||||
Person_evidence | WBPerson567 | ||||||||
Curator_confirmed | WBPerson567 | ||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Concise_description | The hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos. | ||||||||
Molecular_info (5) | |||||||||
Experimental_info | RNAi_result (5) | ||||||||
WB_RNAi_result (13) | |||||||||
Expr_pattern (5) | |||||||||
Gene_regulation | Trans_regulator | cgc4735_hcp-1_b | |||||||
cgc4735_hcp-4 | |||||||||
Trans_target | cgc4735_hcp-3 | ||||||||
Y2H_target | Y2H007532 | ||||||||
Reference (14) | |||||||||
Remark | Sequence connection from [Moore LL, Roth MB]. krb 13/11/01 | ||||||||
Method | Gene |