![Adult](JavaScript:void
window.open("/cgi-bin/rnaidb/popUpImage.cgi?imgName=N2wormfinal.png",
"RNAiDB Help","toolbar=no, location=no, directories=no,
status=no, menubar=no, scrollbars=yes, resizable=no,
copyhistory=no, width=1000, height=550"))
Gene: F58B6.3 
| F58B6.3 | SMap | S_parent | Sequence | F58B6 |
|---|---|---|---|---|
| Chromosome | III | |||
| Identity (5) | ||||
| Gene_info | Gene_class | par | ||
| Allele (5) | ||||
| Phenotype | it46ts mat : homozygous hermaphrodites produce 90% (16x) to 99% (25x) arrested embryos escapers sterile; abnormal early cleavages defective P granule localization. ES3 (progeny). NA4 (it5ts : weaker phenotype e2030 : grandchildless). | |||
| See also e2030 | ||||
| [C.elegansII] it46ts,mat : homozygous hermaphrodites produce 90% (16C) to 99% (25C) arrested embryos, escapers sterile; abnormal early cleavages, both spindles transverse at 2nd cleavage (failure of P1 rotation), defective P granule localization. ES3 (progeny). OA7: it5ts (weaker phenotype), e2030 (Mes, grandchildless),it87 (weak),jb2, etc. All ts; temp shift indicates not needed after 2nd cleavage. Cloned: encodes predicted novel protein. Antibody staining indicates specific asymmetric cortical localizations in early blastomeres. [Cheng et al. 1995; KK] | ||||
| Strain (5) | ||||
| GO_term (9) | ||||
| Contained_in_operon | CEOP3056 | |||
| Structured_description | Provisional_description (6) | |||
| Concise_description | par-2 encodes a protein containing a C3HC4-type RING-finger, a specialized type of zinc-finger found in E3 ubiquitin ligase subunits; PAR-2 is required maternally for polarization of the C. elegans zygote along the anterior-posterior (A-P) axis and is asymmetrically localized to the posterior cortex of the one- and two-cell embryo via interdependent interactions with PAR-3, PAR-6, and PKC-3. | |||
| Molecular_info | Corresponding_CDS | F58B6.3a | ||
| F58B6.3b | ||||
| Corresponding_protein | WP:CE25917 | |||
| WP:CE31016 | ||||
| Corresponding_PCR_product | smd_F58B6.3 | |||
| smd_F58B6.3:2 | ||||
| sjj_F58B6.3 | ||||
| Corresponding_RNAi_reagent (5) | ||||
| Experimental_info | RNAi_result | Cenix:238-a3 | ||
| JA:F58B6.3 | ||||
| Simmer:F58B6.3 | ||||
| WB_RNAi_result (6) | ||||
| Expr_pattern | Expr579 | |||
| Expr1820 | ||||
| Expr2462 | ||||
| Expr2885 | ||||
| Gene_regulation | Trans_regulator | cgc6823_nmy-2 | ||
| cgc6823_par-6 | ||||
| Trans_target | cgc2583_par | |||
| cgc5079_par-2 | ||||
| Interaction | WBInteraction0000117 | |||
| WBInteraction0000118 | ||||
| WBInteraction0000266 | ||||
| WBInteraction0000267 | ||||
| WBInteraction0000427 | ||||
| WBInteraction0000435 | ||||
| WBInteraction0000436 | ||||
| WBInteraction0000784 | ||||
| WBInteraction0001351 | ||||
| WBInteraction0001352 | ||||
| WBInteraction0001371 | ||||
| WBInteraction0001372 | ||||
| WBInteraction0002292 | ||||
| WBInteraction0003101 | ||||
| WBInteraction0003151 | ||||
| WBInteraction0003152 | ||||
| WBInteraction0003324 | ||||
| WBInteraction0003325 | ||||
| WBInteraction0003575 | ||||
| WBInteraction0003576 | ||||
| WBInteraction0003577 | ||||
| WBInteraction0003578 | ||||
| WBInteraction0003579 | ||||
| WBInteraction0003580 | ||||
| WBInteraction0003668 | ||||
| WBInteraction0003669 | ||||
| WBInteraction0003670 | ||||
| WBInteraction0003671 | ||||
| WBInteraction0003672 | ||||
| WBInteraction0003673 | ||||
| Reference (178) | ||||
| Method | Gene |
